%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Tami Bar-Shalita, Anatoly Livshitz, Yulia Levin-Meltz, Debbie Rand, Lisa Deutsch, Jean-Jacques Vatine
Sensory modulation dysfunction is associated with Complex Regional Pain Syndrome
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref002)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref003)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref004)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref003)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref004)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref007)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref007)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref008)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref009)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref002)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref010)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref011)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref012)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref014)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref011)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref015)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref016)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref008)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref011)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref017)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref018)>>
endobj
39 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref011)>>
endobj
40 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref017)>>
endobj
41 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref011)>>
endobj
42 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref017)>>
endobj
43 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref019)>>
endobj
44 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref020)>>
endobj
45 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref011)>>
endobj
46 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref001)>>
endobj
47 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref003)>>
endobj
48 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref006)>>
endobj
49 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref008)>>
endobj
50 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref021)>>
endobj
51 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref022)>>
endobj
52 0 obj
<>/Border[0 0 0]/A 55 0 R>>
endobj
55 0 obj
<>
endobj
53 0 obj
<>/Border[0 0 0]/A 56 0 R>>
endobj
56 0 obj
<>
endobj
54 0 obj
<>/Border[0 0 0]/A 57 0 R>>
endobj
57 0 obj
<>
endobj
14 0 obj
[58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R]
endobj
58 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 680.2299 m
199.9998 680.2299 l
199.9998 680.73 l
575.9997 680.73 l
f*
0.83 0.64 0.02 0 k
322.8661 588.926 m
327.5717 588.926 l
h
f*
332.0504 588.926 m
336.8126 588.926 l
h
f*
511.5969 549.9213 m
516.3591 549.9213 l
h
f*
520.8378 549.9213 m
525.6 549.9213 l
h
f*
433.0772 523.8992 m
437.8394 523.8992 l
h
f*
442.2614 523.8992 m
447.0236 523.8992 l
h
f*
451.5024 523.8992 m
456.2646 523.8992 l
h
f*
330.2929 484.8945 m
335.0551 484.8945 l
h
f*
339.5339 484.8945 m
344.2961 484.8945 l
h
f*
476.674 484.8945 m
481.4362 484.8945 l
h
f*
514.3181 471.9118 m
519.0803 471.9118 l
h
f*
523.5024 471.9118 m
528.2646 471.9118 l
h
f*
486.8787 458.9291 m
491.6409 458.9291 l
h
f*
429.052 445.9465 m
438.5764 445.9465 l
h
f*
270.7087 406.9417 m
280.1764 406.9417 l
h
f*
434.8913 341.915 m
444.4157 341.915 l
h
f*
449.5748 341.915 m
459.0992 341.915 l
h
f*
230.9669 315.9496 m
240.4346 315.9496 l
h
f*
244.9134 315.9496 m
254.4378 315.9496 l
h
f*
258.8598 315.9496 m
268.3843 315.9496 l
h
f*
440.5606 302.9102 m
445.3228 302.9102 l
h
f*
542.3811 250.9228 m
551.9055 250.9228 l
h
f*
556.3843 250.9228 m
565.9087 250.9228 l
h
f*
328.7055 224.9008 m
338.2299 224.9008 l
h
f*
252.1701 211.9181 m
261.6945 211.9181 l
h
f*
266.1165 211.9181 m
275.6409 211.9181 l
h
f*
540.7937 211.9181 m
550.3181 211.9181 l
h
f*
554.7969 211.9181 m
564.3213 211.9181 l
h
f*
389.8772 185.8961 m
399.4016 185.8961 l
h
f*
274.7906 146.948 m
284.315 146.948 l
h
f*
524.0693 146.948 m
533.5937 146.948 l
h
f*
527.6976 133.9087 m
532.4598 133.9087 l
h
f*
344.9764 120.926 m
349.7386 120.926 l
h
f*
354.1606 120.926 m
358.9228 120.926 l
h
f*
468.4535 94.9039 m
473.2157 94.9039 l
h
f*
477.6378 94.9039 m
487.1622 94.9039 l
h
f*
491.6409 94.9039 m
501.1654 94.9039 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F7 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(probability)Tj
4.7084 0 Td
(clinical)Tj
3.1748 0 Td
(tool)Tj
/F0 1 Tf
1.8082 0 Td
(a)Tj
0.7698 0 Td
(simple)Tj
3.0734 0 Td
(evaluation)Tj
4.7144 0 Td
(to)Tj
1.0444 0 Td
(be)Tj
1.3188 0 Td
(applied)Tj
3.3956 0 Td
(by)Tj
1.2652 0 Td
(clinicians)Tj
4.2131 0 Td
(in)Tj
0.9847 0 Td
(order)Tj
2.5243 0 Td
(to)Tj
1.0444 0 Td
(identify)Tj
-34.0395 -1.474 Td
(those)Tj
2.6377 0 Td
(at)Tj
1.0503 0 Td
(risk)Tj
1.7545 0 Td
(for)Tj
1.3785 0 Td
(CRPS)Tj
2.9778 0 Td
(immediately)Tj
5.4903 0 Td
(after)Tj
2.202 0 Td
(injury.)Tj
2.8526 0 Td
(Further)Tj
3.4135 0 Td
(research)Tj
4.0699 0 Td
(is)Tj
0.931 0 Td
(needed.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 619.9937 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(1.)Tj
1.0441 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 602.9858 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Complex)Tj
3.8607 0 Td
(Regional)Tj
3.7304 0 Td
(Pain)Tj
2.0296 0 Td
(Syndrome)Tj
4.3483 0 Td
(\(CRPS\))Tj
3.2201 0 Td
(develops)Tj
3.6794 0 Td
(in)Tj
1.0375 0 Td
(47%)Tj
2.4491 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3675 0 Td
(after)Tj
2.0353 0 Td
(limb)Tj
2.0579 0 Td
(fractures,)Tj
-32.8306 -1.2982 Td
(limb)Tj
2.0579 0 Td
(surgery)Tj
3.1974 0 Td
(or)Tj
1.0942 0 Td
(other)Tj
2.3528 0 Td
(injuries)Tj
3.2428 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2585 0 Td
(2)Tj
0 g
(])Tj
1.0375 0 Td
(and)Tj
1.7291 0 Td
(is)Tj
0.8448 0 Td
(characterized)Tj
5.5615 0 Td
(by)Tj
1.1792 0 Td
(continuing)Tj
4.6261 0 Td
(\(evoked)Tj
3.3902 0 Td
(and/or)Tj
2.9367 0 Td
(sponta-)Tj
-34.5087 -1.2983 Td
(neous\))Tj
2.9253 0 Td
(pain)Tj
1.9899 0 Td
(that)Tj
1.7745 0 Td
(is)Tj
0.8504 0 Td
(regional)Tj
3.4809 0 Td
(related,)Tj
3.1691 0 Td
(disproportionate)Tj
6.9448 0 Td
(in)Tj
1.0375 0 Td
(its)Tj
1.1452 0 Td
(time)Tj
2.0296 0 Td
(duration)Tj
3.702 0 Td
(and/or)Tj
2.9367 0 Td
(pain)Tj
1.9899 0 Td
(intensity)Tj
-33.9758 -1.3039 Td
(after)Tj
2.0239 0 Td
(trauma)Tj
3.0954 0 Td
(or)Tj
1.0885 0 Td
(other)Tj
2.3414 0 Td
(lesions.)Tj
3.1521 0 Td
(Further,)Tj
3.4809 0 Td
(the)Tj
1.4627 0 Td
(pain)Tj
1.9786 0 Td
(typically)Tj
3.5489 0 Td
(has)Tj
1.5364 0 Td
(a)Tj
0.6463 0 Td
(distal)Tj
2.3414 0 Td
(predominance)Tj
6.0264 0 Td
(of)Tj
1.0035 0 Td
(abnormal)Tj
-33.7264 -1.2983 Td
(sensory,)Tj
3.4695 0 Td
(motor,)Tj
2.948 0 Td
(sudomotor,)Tj
4.8756 0 Td
(vasomotor)Tj
4.4787 0 Td
(edema,)Tj
3.0728 0 Td
(and/or)Tj
2.9366 0 Td
(trophic)Tj
3.1351 0 Td
(characteristics)Tj
5.9017 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2643 0 Td
(4)Tj
0 g
(].)Tj
1.2585 0 Td
(Though)Tj
-33.3408 -1.2982 Td
(the)Tj
1.4683 0 Td
(evolution)Tj
4.0025 0 Td
(of)Tj
1.0148 0 Td
(CRPS)Tj
2.5398 0 Td
(varies,)Tj
2.7553 0 Td
(it)Tj
0.7823 0 Td
(usually)Tj
3.0217 0 Td
(evolves)Tj
3.0898 0 Td
(into)Tj
1.8425 0 Td
(severe)Tj
2.6759 0 Td
(state)Tj
2.0352 0 Td
(of)Tj
1.0148 0 Td
(disablement)Tj
5.074 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(affected)Tj
-33.8227 -1.3039 Td
(limb,)Tj
2.2847 0 Td
(which)Tj
2.6475 0 Td
(adversely)Tj
3.9175 0 Td
(impacts)Tj
3.3448 0 Td
(function)Tj
3.6283 0 Td
(and)Tj
1.7292 0 Td
(quality)Tj
2.9536 0 Td
(of)Tj
1.0148 0 Td
(life)Tj
1.4457 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9241 0 Td
(6)Tj
0 g
(].)Tj
1.2585 0 Td
(Consequently,)Tj
5.9584 0 Td
(the)Tj
1.4684 0 Td
(individ-)Tj
-33.8341 -1.2983 Td
(ual)Tj
1.4286 0 Td
(burden)Tj
3.1238 0 Td
(that)Tj
1.7801 0 Td
(CRPS)Tj
2.5398 0 Td
(enforces)Tj
3.566 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(costs)Tj
2.1713 0 Td
(that)Tj
1.7801 0 Td
(society)Tj
2.9537 0 Td
(has)Tj
1.542 0 Td
(to)Tj
1.0262 0 Td
(bear)Tj
1.9559 0 Td
(are)Tj
1.4456 0 Td
(vast;)Tj
1.9956 0 Td
(patients)Tj
3.3676 0 Td
(with)Tj
-33.8738 -1.2983 Td
(CRPS)Tj
2.5398 0 Td
(who)Tj
1.9389 0 Td
(have)Tj
2.0579 0 Td
(prolonged)Tj
4.3313 0 Td
(pain,)Tj
2.2167 0 Td
(typically)Tj
3.5603 0 Td
(reduce)Tj
2.9197 0 Td
(working)Tj
3.5602 0 Td
(hours)Tj
2.5115 0 Td
(or)Tj
1.0999 0 Td
(are)Tj
1.4456 0 Td
(unemployed,)Tj
5.4425 0 Td
(thus)Tj
1.9332 0 Td
(sal-)Tj
-35.5575 -1.3039 Td
(ary)Tj
1.4796 0 Td
(income)Tj
3.2088 0 Td
(is)Tj
0.8504 0 Td
(usually)Tj
3.0161 0 Td
(decreased)Tj
4.1328 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2643 0 Td
(7)Tj
0 g
(])Tj
1.0318 0 Td
(while)Tj
2.3697 0 Td
(overall)Tj
2.9027 0 Td
(costs)Tj
2.1713 0 Td
(are)Tj
1.4514 0 Td
(elevated)Tj
3.4469 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.6044 0 Td
(The)Tj
1.7801 0 Td
(incidence)Tj
4.0762 0 Td
(of)Tj
-34.7865 -1.2983 Td
(CRPS)Tj
2.5398 0 Td
(in)Tj
1.0318 0 Td
(Europe)Tj
3.1407 0 Td
(per)Tj
1.5307 0 Td
(year)Tj
1.9049 0 Td
(is)Tj
0.8447 0 Td
(estimated)Tj
4.0762 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1452 0 Td
(about)Tj
2.4944 0 Td
(26.2)Tj
1.8766 0 Td
(per)Tj
1.5307 0 Td
(100,000)Tj
3.2995 0 Td
(individuals)Tj
4.6487 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(9)Tj
0 g
(])Tj
1.0375 0 Td
(and)Tj
-33.3862 -1.2982 Td
(approximately)Tj
5.9753 0 Td
(200,000)Tj
3.2996 0 Td
(Americans)Tj
4.5524 0 Td
(are)Tj
1.4456 0 Td
(diagnosed)Tj
4.286 0 Td
(with)Tj
1.9956 0 Td
(CRPS)Tj
2.5398 0 Td
(every)Tj
2.3471 0 Td
(year)Tj
1.9048 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5988 0 Td
(Total)Tj
2.3187 0 Td
(annual)Tj
-32.2637 -1.2983 Td
(income)Tj
3.2087 0 Td
(loss)Tj
1.6952 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(US)Tj
1.4286 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(CRPS)Tj
2.5399 0 Td
(exceeds)Tj
3.2654 0 Td
(US$1)Tj
2.3868 0 Td
(billion)Tj
2.8063 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
-21.3674 -1.3039 Td
(There)Tj
2.5795 0 Td
(are)Tj
1.4513 0 Td
(two)Tj
1.7064 0 Td
(types)Tj
2.2734 0 Td
(of)Tj
1.0148 0 Td
(CRPS;)Tj
2.7666 0 Td
(CRPS)Tj
2.5398 0 Td
(that)Tj
1.7802 0 Td
(involves)Tj
3.4809 0 Td
(distinct)Tj
3.2145 0 Td
(nerve)Tj
2.4378 0 Td
(injury)Tj
2.6475 0 Td
(\(Type)Tj
2.5682 0 Td
(2\),)Tj
1.2585 0 Td
(and)Tj
1.7292 0 Td
(CRPS)Tj
-34.6448 -1.2983 Td
(where)Tj
2.6475 0 Td
(there)Tj
2.2677 0 Td
(is)Tj
0.8447 0 Td
(no)Tj
1.2756 0 Td
(identifiable)Tj
4.7168 0 Td
(nerve)Tj
2.4435 0 Td
(injury)Tj
2.6475 0 Td
(\(Type)Tj
2.5682 0 Td
(1;)Tj
0.9184 0 Td
(identified)Tj
4.0592 0 Td
(by)Tj
1.1792 0 Td
(a)Tj
0.6576 0 Td
(noxious)Tj
3.4016 0 Td
(event)Tj
2.3697 0 Td
(or)Tj
1.0999 0 Td
(a)Tj
0.6519 0 Td
(cause)Tj
2.3925 0 Td
(of)Tj
-36.1415 -1.2982 Td
(immobilization\))Tj
6.7294 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
2.0749 0 Td
(The)Tj
1.7802 0 Td
(etiology)Tj
3.3902 0 Td
(of)Tj
1.0148 0 Td
(CRPS)Tj
2.5398 0 Td
(is)Tj
0.8504 0 Td
(still)Tj
1.6384 0 Td
(unclear)Tj
3.1918 0 Td
(and)Tj
1.7291 0 Td
(several)Tj
2.9367 0 Td
(underlying)Tj
4.6034 0 Td
(pathophysi-)Tj
-32.4791 -1.3039 Td
(ological)Tj
3.3165 0 Td
(mechanisms)Tj
5.2043 0 Td
(have)Tj
2.058 0 Td
(been)Tj
2.126 0 Td
(indicated.)Tj
4.1612 0 Td
(These)Tj
2.5682 0 Td
(consist)Tj
2.982 0 Td
(of)Tj
1.0148 0 Td
(genetic)Tj
3.0727 0 Td
(and)Tj
1.7291 0 Td
(psychological)Tj
5.6013 0 Td
(factors;)Tj
-33.8341 -1.2983 Td
(somatosensory)Tj
6.1738 0 Td
(innervation)Tj
4.8869 0 Td
(alterations;)Tj
4.6374 0 Td
(peripheral)Tj
4.3143 0 Td
(and)Tj
1.7348 0 Td
(central)Tj
2.965 0 Td
(sensitization;)Tj
5.4369 0 Td
(altered)Tj
2.948 0 Td
(sympa-)Tj
-33.0971 -1.2983 Td
(thetic)Tj
2.4547 0 Td
(nervous)Tj
3.4186 0 Td
(system)Tj
2.9367 0 Td
(processing;)Tj
4.6884 0 Td
(augmented)Tj
4.6885 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(local)Tj
2.0807 0 Td
(and)Tj
1.7291 0 Td
(systemic)Tj
3.6283 0 Td
(inflammatory)Tj
5.7089 0 Td
(cyto-)Tj
-34.7241 -1.3039 Td
(kines;)Tj
2.5398 0 Td
(lower)Tj
2.4548 0 Td
(systemic)Tj
3.6283 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(anti-inflammatory)Tj
7.6081 0 Td
(cytokines;)Tj
4.2236 0 Td
(lower)Tj
2.4492 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(circulating)Tj
-29.6842 -1.2983 Td
(catecholamines;)Tj
6.582 0 Td
(and)Tj
1.7291 0 Td
(regulating)Tj
4.2689 0 Td
(neuroplasticity)Tj
6.1625 0 Td
(difficulties)Tj
4.405 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(].)Tj
3.549 0 Td
(Early)Tj
2.296 0 Td
(diagnosis)Tj
3.9572 0 Td
(of)Tj
1.0148 0 Td
(CRPS)Tj
-33.9645 -1.2982 Td
(and)Tj
1.7291 0 Td
(prompt)Tj
3.2485 0 Td
(rehabilitation)Tj
5.6182 0 Td
(is)Tj
0.8504 0 Td
(widely)Tj
2.8233 0 Td
(recommended)Tj
6.0321 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(best)Tj
1.8085 0 Td
(way)Tj
1.7914 0 Td
(to)Tj
1.0262 0 Td
(achieve)Tj
3.1748 0 Td
(optimum)Tj
3.9741 0 Td
(out-)Tj
-34.5654 -1.2983 Td
(comes)Tj
2.7552 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3946 0 Td
(16)Tj
0 g
(].)Tj
1.7405 0 Td
(However,)Tj
4.0762 0 Td
(failure)Tj
2.7779 0 Td
(to)Tj
1.0262 0 Td
(consider)Tj
3.6453 0 Td
(complicating)Tj
5.4368 0 Td
(factors)Tj
2.9083 0 Td
(delays)Tj
2.6646 0 Td
(the)Tj
1.4683 0 Td
(diagnosis,)Tj
4.1839 0 Td
(and)Tj
-35.8126 -1.3039 Td
(improper)Tj
4.0138 0 Td
(treatment)Tj
4.1329 0 Td
(can)Tj
1.627 0 Td
(lead)Tj
1.8539 0 Td
(to)Tj
1.0261 0 Td
(CRPS)Tj
2.5399 0 Td
(with)Tj
1.9955 0 Td
(severe)Tj
2.6759 0 Td
(disability)Tj
3.8494 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
-22.5182 -1.2983 Td
(Different)Tj
3.8664 0 Td
(potential)Tj
3.7587 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
2.9027 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(CRPS)Tj
2.5398 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.1203 0 Td
(suggested.)Tj
4.303 0 Td
(Risk)Tj
1.9672 0 Td
(is)Tj
0.8448 0 Td
(higher)Tj
2.8006 0 Td
(in)Tj
-36.3059 -1.2982 Td
(females,)Tj
3.4298 0 Td
(mostly)Tj
2.9027 0 Td
(postmenopausal)Tj
6.7124 0 Td
(women;)Tj
3.4186 0 Td
(individuals)Tj
4.6431 0 Td
(who)Tj
1.9275 0 Td
(have)Tj
2.0523 0 Td
(suffered)Tj
3.4242 0 Td
(an)Tj
1.1962 0 Td
(ankle)Tj
2.3585 0 Td
(injury)Tj
2.6362 0 Td
(includ-)Tj
-34.7015 -1.304 Td
(ing)Tj
1.5023 0 Td
(dislocation)Tj
4.6034 0 Td
(or)Tj
1.0999 0 Td
(an)Tj
1.2019 0 Td
(intraarticular)Tj
5.5105 0 Td
(fracture,)Tj
3.5829 0 Td
(and)Tj
1.7348 0 Td
(a)Tj
0.652 0 Td
(wrist)Tj
2.1997 0 Td
(fracture;)Tj
3.5829 0 Td
(those)Tj
2.3414 0 Td
(who)Tj
1.9389 0 Td
(are)Tj
1.4457 0 Td
(immobilized;)Tj
-31.3963 -1.2982 Td
(and)Tj
1.7291 0 Td
(when)Tj
2.4037 0 Td
(the)Tj
1.4684 0 Td
(pain)Tj
1.9899 0 Td
(level)Tj
2.0126 0 Td
(is)Tj
0.8504 0 Td
(enhanced,)Tj
4.3029 0 Td
(higher)Tj
2.8006 0 Td
(than)Tj
2.0296 0 Td
(usual,)Tj
2.5399 0 Td
(in)Tj
1.0374 0 Td
(early)Tj
2.1487 0 Td
(stages)Tj
2.5625 0 Td
(of)Tj
1.0148 0 Td
(post)Tj
1.9048 0 Td
(trauma)Tj
3.1011 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(17)Tj
0 g
(].)Tj
-35.6369 -1.2983 Td
(Furthermore,)Tj
5.6125 0 Td
(a)Tj
0.652 0 Td
(significant)Tj
4.3937 0 Td
(association)Tj
4.6261 0 Td
(between)Tj
3.5262 0 Td
(CRPS)Tj
2.5399 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.6576 0 Td
(prior)Tj
2.2507 0 Td
(diagnosis)Tj
3.9628 0 Td
(of)Tj
1.0148 0 Td
(migraine)Tj
3.8154 0 Td
(or)Tj
-34.7808 -1.3039 Td
(osteoporosis)Tj
5.2043 0 Td
(has)Tj
1.5477 0 Td
(been)Tj
2.1203 0 Td
(reported)Tj
3.6567 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(])Tj
1.8539 0 Td
(although)Tj
3.753 0 Td
(these)Tj
2.2564 0 Td
(potential)Tj
3.7587 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
2.9026 0 Td
(were)Tj
2.1203 0 Td
(not)Tj
1.5761 0 Td
(confirmed)Tj
-32.4678 -1.2983 Td
(across)Tj
2.6758 0 Td
(trials)Tj
2.1997 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(17)Tj
0 g
(].)Tj
1.7348 0 Td
(Evidence)Tj
3.8608 0 Td
(for)Tj
1.3833 0 Td
(robust)Tj
2.7949 0 Td
(genetic)Tj
3.0671 0 Td
(associations)Tj
4.9889 0 Td
(has)Tj
1.5477 0 Td
(not)Tj
1.5704 0 Td
(been)Tj
2.126 0 Td
(identified)Tj
4.0535 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(17)Tj
0 g
(],)Tj
-35.4782 -1.2982 Td
(and)Tj
1.7291 0 Td
(psychological)Tj
5.6012 0 Td
(factors)Tj
2.9027 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(depression,)Tj
4.7565 0 Td
(neuroticism,)Tj
5.2554 0 Td
(anxiety)Tj
3.1124 0 Td
(or)Tj
1.0999 0 Td
(anger)Tj
2.4604 0 Td
(have)Tj
2.0636 0 Td
(also)Tj
1.7688 0 Td
(not)Tj
1.5704 0 Td
(been)Tj
-35.3931 -1.3039 Td
(shown)Tj
2.8459 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(predictors)Tj
4.286 0 Td
(for)Tj
1.3889 0 Td
(CRPS)Tj
2.5399 0 Td
(development)Tj
5.4084 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
2.075 0 Td
(Recently)Tj
3.6623 0 Td
(however,)Tj
3.8381 0 Td
(higher)Tj
2.8006 0 Td
(prevalence)Tj
4.4901 0 Td
(of)Tj
-35.5122 -1.2983 Td
(posttraumatic)Tj
5.7769 0 Td
(stress)Tj
2.3981 0 Td
(disorder)Tj
3.5716 0 Td
(\(PTSD\))Tj
3.2825 0 Td
(in)Tj
1.0375 0 Td
(CRPS,)Tj
2.7666 0 Td
(compared)Tj
4.2406 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(general)Tj
3.1351 0 Td
(population)Tj
4.5921 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
-35.0246 -1.2983 Td
(other)Tj
2.347 0 Td
(limb)Tj
2.058 0 Td
(pain)Tj
1.9899 0 Td
(disorders,)Tj
4.1612 0 Td
(was)Tj
1.7008 0 Td
(reported)Tj
3.6567 0 Td
(indicating)Tj
4.2689 0 Td
(that)Tj
1.7801 0 Td
(PTSD)Tj
2.6022 0 Td
(may)Tj
1.9276 0 Td
(serve)Tj
2.2507 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(risk)Tj
1.7121 0 Td
(factor)Tj
2.5455 0 Td
(for)Tj
-34.6731 -1.2982 Td
(developing)Tj
4.5977 0 Td
(CRPS)Tj
2.5398 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
2.0807 0 Td
(Importantly,)Tj
5.278 0 Td
(while)Tj
2.3698 0 Td
(factors)Tj
2.9026 0 Td
(for)Tj
1.3833 0 Td
(CRPS)Tj
2.5399 0 Td
(onset)Tj
2.3584 0 Td
(are)Tj
1.4513 0 Td
(still)Tj
1.6384 0 Td
(elusive)Tj
2.9254 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(],)Tj
2.0749 0 Td
(identify-)Tj
-34.1402 -1.304 Td
(ing)Tj
1.5023 0 Td
(those)Tj
2.3357 0 Td
(at)Tj
0.9525 0 Td
(risk)Tj
1.7121 0 Td
(for)Tj
1.389 0 Td
(CRPS)Tj
2.5398 0 Td
(prior)Tj
2.2507 0 Td
(to)Tj
1.0261 0 Td
(surgical)Tj
3.3165 0 Td
(interventions,)Tj
5.7657 0 Td
(immediate)Tj
4.5013 0 Td
(post-trauma)Tj
5.1364 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(],)Tj
1.6044 0 Td
(or)Tj
1.0942 0 Td
(very)Tj
-35.1267 -1.2982 Td
(early)Tj
2.1486 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(condition,)Tj
4.337 0 Td
(is)Tj
0.8504 0 Td
(warranted)Tj
4.3143 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(6)Tj
0 g
(].)Tj
-14.2185 -1.2983 Td
(A)Tj
0.907 0 Td
(distinguished)Tj
5.5899 0 Td
(body)Tj
2.2167 0 Td
(of)Tj
1.0148 0 Td
(literature)Tj
3.8778 0 Td
(about)Tj
2.4944 0 Td
(CRPS)Tj
2.5399 0 Td
(supports)Tj
3.685 0 Td
(the)Tj
1.4683 0 Td
(involvement)Tj
5.2101 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(central)Tj
2.965 0 Td
(ner-)Tj
-35.6482 -1.3039 Td
(vous)Tj
2.0692 0 Td
(system)Tj
2.9367 0 Td
(in)Tj
1.0375 0 Td
(terms)Tj
2.4944 0 Td
(of)Tj
1.0148 0 Td
(sensory)Tj
3.2485 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8199 0 Td
(as)Tj
1.0148 0 Td
(pain)Tj
1.9842 0 Td
(processing)Tj
4.4674 0 Td
(changes)Tj
3.4015 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(21)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.4003 0 Td
(22)Tj
0 g
(].)Tj
1.7348 0 Td
(Specifically,)Tj
4.9152 0 Td
(not)Tj
-35.8126 -1.2983 Td
(only)Tj
1.9729 0 Td
(have)Tj
2.0636 0 Td
(impairments)Tj
5.3461 0 Td
(in)Tj
1.0374 0 Td
(endogenous)Tj
5.057 0 Td
(pain)Tj
1.9899 0 Td
(inhibitory)Tj
4.235 0 Td
(pathways)Tj
3.9288 0 Td
(evident,)Tj
3.3902 0 Td
(but)Tj
1.5533 0 Td
(these)Tj
2.2564 0 Td
(were)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 472.2519 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(SMD)Tj
2.4165 0 Td
(is)Tj
0.9213 0 Td
(associated)Tj
4.9181 0 Td
(with)Tj
1.963 0 Td
(CRPS)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02013)Tj
4.089 0 Td
(54)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(9,)Tj
1.0418 0 Td
(2018)Tj
34.5758 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(13)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
124.7244 646.6394 m
162.9921 646.6394 l
h
f*
36 635.6409 m
81.6945 635.6409 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F10 1 Tf
1 TL
-0.025 Tc
0 0 Td
(these)Tj
2.211 0 Td
(authors)Tj
3.0473 0 Td
(are)Tj
1.3677 0 Td
(articulated)Tj
4.0606 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3677 0 Td
(`author)Tj
-12.9402 -1.3748 Td
(contributio)Tj
3.9897 0 Td
(ns')Tj
1.3111 0 Td
(section.)Tj
/F9 1 Tf
-5.3008 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(declare)Tj
2.8843 0 Td
(the)Tj
-15.704 -1.3748 Td
(following)Tj
3.5858 0 Td
(interest:)Tj
3.1961 0 Td
(Lisa)Tj
1.7291 0 Td
(Deutsch)Tj
3.2741 0 Td
(is)Tj
0.8362 0 Td
(affiliated)Tj
3.3024 0 Td
(with)Tj
1.7788 0 Td
(the)Tj
-17.7025 -1.3748 Td
(commercial)Tj
4.5779 0 Td
(company)Tj
3.6638 0 Td
(BioStat)Tj
2.6434 0 Td
(s)Tj
0.6449 0 Td
(Statistical)Tj
-11.53 -1.3748 Td
(Consulting)Tj
4.174 0 Td
(ltd,)Tj
1.3677 0 Td
(Modiin,)Tj
3.0048 0 Td
(Israel)Tj
2.2394 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(https://w)Tj
3.5575 0 Td
(ww.)Tj
-14.3434 -1.3748 Td
(ldbiostats)Tj
3.5787 0 Td
(.com/)Tj
0 g
(\).)Tj
2.8843 0 Td
(There)Tj
2.3173 0 Td
(are)Tj
1.3678 0 Td
(no)Tj
1.1693 0 Td
(patents,)Tj
3.1606 0 Td
(products)Tj
3.5221 0 Td
(in)Tj
-18.0001 -1.3748 Td
(developm)Tj
3.6283 0 Td
(ent,)Tj
1.5945 0 Td
(or)Tj
1.0063 0 Td
(markete)Tj
2.9977 0 Td
(d)Tj
0.6945 0 Td
(products)Tj
3.5221 0 Td
(to)Tj
0.9496 0 Td
(declare.)Tj
-14.393 -1.3748 Td
(This)Tj
1.7787 0 Td
(does)Tj
2.0126 0 Td
(not)Tj
1.4244 0 Td
(alter)Tj
1.8142 0 Td
(the)Tj
1.3748 0 Td
(authors)Tj
2.8205 0 Td
(')Tj
0.4181 0 Td
(adherenc)Tj
3.4087 0 Td
(e)Tj
0.6449 0 Td
(to)Tj
0.9496 0 Td
(all)Tj
-16.6465 -1.3749 Td
(PLOS)Tj
2.3315 0 Td
(ONE)Tj
1.8708 0 Td
(policies)Tj
3.0119 0 Td
(on)Tj
1.1622 0 Td
(sharing)Tj
2.9835 0 Td
(data)Tj
1.7929 0 Td
(and)Tj
ET
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
endstream
endobj
65 0 obj
<>stream
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
endstream
endobj
77 0 obj
<>stream
endstream
endobj
78 0 obj
<>stream
endstream
endobj
79 0 obj
<>stream
endstream
endobj
80 0 obj
<>stream
BT
14.7402 -13.1245 Td
(materials.)Tj
ET
Q
endstream
endobj
81 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 83 0 R/Contents 84 0 R/TrimBox[0 0 612 792]>>
endobj
83 0 obj
[85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R 108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R]
endobj
85 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref023)>>
endobj
86 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref024)>>
endobj
87 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref025)>>
endobj
88 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref026)>>
endobj
89 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref023)>>
endobj
90 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref027)>>
endobj
91 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref028)>>
endobj
92 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref031)>>
endobj
93 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref028)>>
endobj
94 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref032)>>
endobj
95 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref033)>>
endobj
96 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref027)>>
endobj
97 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref034)>>
endobj
98 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref039)>>
endobj
99 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref037)>>
endobj
100 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref040)>>
endobj
101 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref043)>>
endobj
102 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref027)>>
endobj
103 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref029)>>
endobj
104 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref032)>>
endobj
105 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref034)>>
endobj
106 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref038)>>
endobj
107 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref042)>>
endobj
108 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref028)>>
endobj
109 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref040)>>
endobj
110 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref041)>>
endobj
111 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref043)>>
endobj
112 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref008)>>
endobj
113 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref001)>>
endobj
114 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref001)>>
endobj
115 0 obj
<>/Border[0 0 0]/A 116 0 R>>
endobj
116 0 obj
<>
endobj
84 0 obj
[117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R]
endobj
117 0 obj
<>stream
q
0.83 0.64 0.02 0 k
318.5575 706.337 m
328.0819 706.337 l
h
f*
332.5039 706.337 m
342.0283 706.337 l
h
f*
460.4031 706.337 m
469.9276 706.337 l
h
f*
261.5244 680.315 m
270.9921 680.315 l
h
f*
203.4142 654.3496 m
212.9386 654.3496 l
h
f*
336.6992 615.3449 m
346.2236 615.3449 l
h
f*
433.9276 602.3055 m
443.452 602.3055 l
h
f*
448.611 602.3055 m
458.1354 602.3055 l
h
f*
426.7843 589.3228 m
436.252 589.3228 l
h
f*
440.7307 589.3228 m
450.2551 589.3228 l
h
f*
454.6772 589.3228 m
464.2016 589.3228 l
h
f*
285.3354 563.3008 m
294.8598 563.3008 l
h
f*
299.3386 563.3008 m
308.8063 563.3008 l
h
f*
314.022 563.3008 m
323.4898 563.3008 l
h
f*
376.2142 563.3008 m
385.7386 563.3008 l
h
f*
390.2173 563.3008 m
399.7417 563.3008 l
h
f*
404.9008 563.3008 m
414.4252 563.3008 l
h
f*
407.6787 550.3181 m
417.2031 550.3181 l
h
f*
421.6252 550.3181 m
431.1496 550.3181 l
h
f*
435.6283 550.3181 m
445.0961 550.3181 l
h
f*
449.5748 550.3181 m
459.0992 550.3181 l
h
f*
464.2583 550.3181 m
473.7827 550.3181 l
h
f*
478.2047 550.3181 m
487.7291 550.3181 l
h
f*
495.6094 537.3354 m
505.1339 537.3354 l
h
f*
374.6835 485.348 m
384.2079 485.348 l
h
f*
388.6866 485.348 m
398.1543 485.348 l
h
f*
203.4142 459.326 m
212.9386 459.326 l
h
f*
411.0236 407.3386 m
415.7291 407.3386 l
h
f*
456.7748 250.9228 m
461.537 250.9228 l
h
f*
523.7858 172.9134 m
528.548 172.9134 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(pain)Tj
1.9843 0 Td
(severity)Tj
3.2768 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(24)Tj
0 g
(],)Tj
1.7405 0 Td
(showing)Tj
3.5773 0 Td
(pain)Tj
1.9899 0 Td
(hyperalgesia)Tj
5.142 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
2.0806 0 Td
(Moreover,)Tj
4.3937 0 Td
(reported)Tj
3.6623 0 Td
(sen-)Tj
-35.8353 -1.3039 Td
(sory)Tj
1.9105 0 Td
(changes)Tj
3.4072 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(contralateral)Tj
5.2554 0 Td
(hand)Tj
2.2564 0 Td
(were)Tj
2.1203 0 Td
(found)Tj
2.6192 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
1.4684 0 Td
(ones)Tj
2.0579 0 Td
(occurring)Tj
4.1272 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
-35.0189 -1.2982 Td
(affected)Tj
3.3278 0 Td
(hand,)Tj
2.4831 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(],)Tj
2.075 0 Td
(indicating)Tj
4.2689 0 Td
(central)Tj
2.9651 0 Td
(sensory)Tj
3.2428 0 Td
(processing)Tj
4.4673 0 Td
(alterations)Tj
4.4107 0 Td
(as)Tj
1.0148 0 Td
(well.)Tj
2.0466 0 Td
(To-date)Tj
3.3676 0 Td
(it)Tj
0.788 0 Td
(is)Tj
0.8504 0 Td
(not)Tj
-35.3081 -1.2983 Td
(clear)Tj
2.1146 0 Td
(whether)Tj
3.4809 0 Td
(these)Tj
2.2507 0 Td
(changes)Tj
3.4072 0 Td
(are)Tj
1.4457 0 Td
(a)Tj
0.6519 0 Td
(consequence)Tj
5.3405 0 Td
(of)Tj
1.0148 0 Td
(or)Tj
1.0998 0 Td
(a)Tj
0.652 0 Td
(predisposition)Tj
5.9584 0 Td
(for)Tj
1.3889 0 Td
(developing)Tj
4.5978 0 Td
(CRPS)Tj
-33.4032 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
1.1962 -1.3039 Td
(Sensory)Tj
3.3562 0 Td
(modulation)Tj
4.8982 0 Td
(dysfunction)Tj
4.9719 0 Td
(\(SMD\),)Tj
3.2202 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.652 0 Td
(type)Tj
1.9048 0 Td
(of)Tj
1.0092 0 Td
(sensory)Tj
3.2428 0 Td
(processing)Tj
4.4617 0 Td
(disorder,)Tj
3.7984 0 Td
(impacting)Tj
-33.5563 -1.2982 Td
(single)Tj
2.5284 0 Td
(or)Tj
1.0999 0 Td
(multiple)Tj
3.5659 0 Td
(sensory)Tj
3.2485 0 Td
(systems,)Tj
3.5206 0 Td
(affecting)Tj
3.6567 0 Td
(the)Tj
1.474 0 Td
(capacity)Tj
3.4696 0 Td
(to)Tj
1.0261 0 Td
(regulate)Tj
3.4072 0 Td
(responses)Tj
4.0989 0 Td
(to)Tj
1.0205 0 Td
(sensory)Tj
3.2485 0 Td
(input)Tj
-35.3648 -1.2983 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6576 0 Td
(graded)Tj
2.9707 0 Td
(and)Tj
1.7291 0 Td
(adaptive)Tj
3.5773 0 Td
(manner)Tj
3.3619 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
2.0806 0 Td
(SMD)Tj
2.3244 0 Td
(greatly)Tj
2.914 0 Td
(limits)Tj
2.4774 0 Td
(and)Tj
1.7292 0 Td
(interferes)Tj
3.9968 0 Td
(with)Tj
1.9956 0 Td
(quality)Tj
2.9593 0 Td
(of)Tj
1.0148 0 Td
(life,)Tj
-34.8205 -1.3039 Td
(work)Tj
2.279 0 Td
(performance)Tj
5.3461 0 Td
(and)Tj
1.7291 0 Td
(participation)Tj
5.3745 0 Td
(in)Tj
1.0318 0 Td
(everyday)Tj
3.7644 0 Td
(routines)Tj
3.5262 0 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(])Tj
3.3222 0 Td
(and)Tj
1.7292 0 Td
(its)Tj
1.1451 0 Td
(prevalence)Tj
4.4844 0 Td
(is)Tj
0.8504 0 Td
(esti-)Tj
-34.5824 -1.2983 Td
(mated)Tj
2.7212 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(516%)Tj
2.9197 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(population,)Tj
4.8189 0 Td
(otherwise)Tj
4.0818 0 Td
(healthy)Tj
3.1351 0 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(32)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3946 0 Td
(33)Tj
0 g
(].)Tj
1.7405 0 Td
(SMD)Tj
2.3244 0 Td
(is)Tj
0.8447 0 Td
(characterized)Tj
5.5616 0 Td
(by:)Tj
-35.9374 -1.2983 Td
(\(i\))Tj
1.1678 0 Td
(sensory)Tj
3.2428 0 Td
(over-responsivene)Tj
7.319 0 Td
(ss)Tj
0.9411 0 Td
(in)Tj
1.0318 0 Td
(which)Tj
2.6533 0 Td
(non-painful)Tj
5.0002 0 Td
(stimuli)Tj
3.0104 0 Td
(are)Tj
1.4457 0 Td
(perceived)Tj
4.0535 0 Td
(as)Tj
1.0148 0 Td
(abnormally)Tj
-30.8804 -1.3039 Td
(unpleasant,)Tj
4.7848 0 Td
(aversive)Tj
3.4072 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(34)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(],)Tj
3.2031 0 Td
(or)Tj
1.0999 0 Td
(painful)Tj
3.0443 0 Td
([)Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(40)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(43)Tj
0 g
(],)Tj
3.2031 0 Td
(and/or)Tj
2.9367 0 Td
(\(ii\))Tj
1.4343 0 Td
(sensory)Tj
3.2485 0 Td
(under-responsive-)Tj
-29.8429 -1.2982 Td
(ness)Tj
1.9105 0 Td
(demonstrated)Tj
5.7656 0 Td
(by)Tj
1.1792 0 Td
(reduced)Tj
3.4469 0 Td
(responses)Tj
4.0932 0 Td
(to)Tj
1.0262 0 Td
(stimuli)Tj
3.0047 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(29)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.4003 0 Td
(32)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3946 0 Td
(34)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(38)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
2.863 0 Td
(42)Tj
0 g
(].)Tj
1.7404 0 Td
(Sensory)Tj
3.3619 0 Td
(over-)Tj
-32.9213 -1.2983 Td
(responsiveness)Tj
6.1454 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1259 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(associated)Tj
4.252 0 Td
(with)Tj
2.0012 0 Td
(daily)Tj
2.1487 0 Td
(pain)Tj
1.9842 0 Td
(sensitivity)Tj
4.2236 0 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(].)Tj
2.0749 0 Td
(Moreover,)Tj
4.3994 0 Td
(lab-)Tj
-35.6936 -1.3039 Td
(oratory)Tj
3.1634 0 Td
(quantitative)Tj
4.9776 0 Td
(sensory)Tj
3.2485 0 Td
(testing)Tj
2.88 0 Td
(has)Tj
1.542 0 Td
(revealed)Tj
3.5263 0 Td
(pain)Tj
1.9842 0 Td
(perception)Tj
4.5184 0 Td
(alterations)Tj
4.4107 0 Td
(in)Tj
1.0375 0 Td
(individuals)Tj
-31.2886 -1.2983 Td
(with)Tj
1.9955 0 Td
(sensory)Tj
3.2485 0 Td
(over-responsiveness;)Tj
8.4812 0 Td
(Children)Tj
3.7927 0 Td
(and)Tj
1.7348 0 Td
(adults)Tj
2.6136 0 Td
(with)Tj
1.9955 0 Td
(sensory)Tj
3.2485 0 Td
(over-responsiveness)Tj
8.2545 0 Td
(have)Tj
-35.3648 -1.2982 Td
(demonstrated)Tj
5.7599 0 Td
(pain)Tj
1.9843 0 Td
(hyper-sensitivity)Tj
6.8711 0 Td
(\(hyperalgesia\))Tj
5.8223 0 Td
(and)Tj
1.7291 0 Td
(intense)Tj
3.0955 0 Td
(prolonged)Tj
4.3313 0 Td
(duration)Tj
3.702 0 Td
(of)Tj
1.0148 0 Td
(pain)Tj
-34.3103 -1.2983 Td
(lingering)Tj
3.821 0 Td
(sensations,)Tj
4.5581 0 Td
(compared)Tj
4.2406 0 Td
(to)Tj
1.0261 0 Td
(controls)Tj
3.481 0 Td
([)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7404 0 Td
(41)Tj
0 g
(],)Tj
1.7348 0 Td
(suggesting)Tj
4.405 0 Td
(compromised)Tj
5.76 0 Td
(endogenous)Tj
-30.767 -1.3039 Td
(pain)Tj
1.9842 0 Td
(modulation)Tj
4.9039 0 Td
(in)Tj
1.0375 0 Td
(individuals)Tj
4.6488 0 Td
(with)Tj
1.9955 0 Td
(sensory)Tj
3.2485 0 Td
(over-responsiveness)Tj
8.2545 0 Td
(who)Tj
1.9388 0 Td
(are)Tj
1.4514 0 Td
(otherwise)Tj
4.0818 0 Td
(healthy)Tj
-33.5449 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(43)Tj
0 g
(].)Tj
1.1962 -1.2983 Td
(This)Tj
1.9899 0 Td
(study)Tj
2.3867 0 Td
(aims)Tj
2.1033 0 Td
(to)Tj
1.0262 0 Td
(explore)Tj
3.1747 0 Td
(the)Tj
1.4684 0 Td
(association)Tj
4.6261 0 Td
(between)Tj
3.5319 0 Td
(CRPS)Tj
2.5399 0 Td
(and)Tj
1.7291 0 Td
(SMD,)Tj
2.5512 0 Td
(specifically)Tj
4.5694 0 Td
(to)Tj
1.0261 0 Td
(examine)Tj
-33.9191 -1.3039 Td
(whether)Tj
3.4752 0 Td
(SMD)Tj
2.3244 0 Td
(could)Tj
2.4548 0 Td
(be)Tj
1.1452 0 Td
(considered)Tj
4.6034 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(risk)Tj
1.7178 0 Td
(factor)Tj
2.5398 0 Td
(for)Tj
1.389 0 Td
(CRPS.)Tj
2.7665 0 Td
(Such)Tj
2.1714 0 Td
(a)Tj
0.6576 0 Td
(simple)Tj
2.8516 0 Td
(and)Tj
1.7292 0 Td
(efficient)Tj
3.4469 0 Td
(mea-)Tj
-34.9396 -1.2982 Td
(sure)Tj
1.9048 0 Td
(to)Tj
1.0205 0 Td
(identify)Tj
3.2995 0 Td
(a)Tj
0.652 0 Td
(potential)Tj
3.7587 0 Td
(risk)Tj
1.7178 0 Td
(for)Tj
1.3833 0 Td
(CRPS)Tj
2.5398 0 Td
(may)Tj
1.9275 0 Td
(encourage)Tj
4.3483 0 Td
(an)Tj
1.2019 0 Td
(earlier)Tj
2.7553 0 Td
(diagnosis,)Tj
4.1839 0 Td
(improve)Tj
3.583 0 Td
(the)Tj
-34.2763 -1.2983 Td
(prognosis,)Tj
4.3483 0 Td
(and)Tj
1.7291 0 Td
(dramatically)Tj
5.1817 0 Td
(reduce)Tj
2.914 0 Td
(the)Tj
1.4683 0 Td
(societal)Tj
3.1805 0 Td
(load)Tj
1.9389 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 379.6724 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(2.)Tj
1.0441 0 Td
(Materials)Tj
4.5118 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 362.7212 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(This)Tj
1.9842 0 Td
(cross-sectional)Tj
6.1058 0 Td
(study)Tj
2.3867 0 Td
(included)Tj
3.7134 0 Td
(a)Tj
0.652 0 Td
(two-group)Tj
4.4503 0 Td
(comparison)Tj
4.9776 0 Td
(between)Tj
3.5263 0 Td
(participants)Tj
4.9606 0 Td
(with)Tj
1.9956 0 Td
(and)Tj
-34.7525 -1.3039 Td
(without)Tj
3.3278 0 Td
(CRPS.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 320.9952 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(2.1)Tj
1.4598 0 Td
(Participants)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 303.9874 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Participants)Tj
5.0002 0 Td
(with)Tj
1.9956 0 Td
(CRPS)Tj
2.5398 0 Td
(were)Tj
2.1203 0 Td
(recruited)Tj
3.8551 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(database)Tj
3.6397 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(Center)Tj
2.948 0 Td
(for)Tj
1.3833 0 Td
(Rehabilitation)Tj
5.8677 0 Td
(of)Tj
-35.5122 -1.2982 Td
(Pain)Tj
2.0295 0 Td
(Syndromes,)Tj
4.9323 0 Td
(Reuth)Tj
2.6192 0 Td
(Rehabilitation)Tj
5.8677 0 Td
(Hospital.)Tj
3.8437 0 Td
(Inclusion)Tj
3.9912 0 Td
(criteria)Tj
3.0727 0 Td
(stipulated)Tj
4.1216 0 Td
(participants)Tj
4.9606 0 Td
(were)Tj
-35.4385 -1.2983 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1508 0 Td
(at)Tj
0.9525 0 Td
(least)Tj
1.9785 0 Td
(18)Tj
1.1736 0 Td
(years)Tj
2.262 0 Td
(of)Tj
1.0148 0 Td
(age)Tj
1.5421 0 Td
(and)Tj
1.7347 0 Td
(experiencing)Tj
5.3632 0 Td
(pain)Tj
1.9842 0 Td
(for)Tj
1.389 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9842 0 Td
(3)Tj
0.6917 0 Td
(months.)Tj
3.5093 0 Td
(CRPS)Tj
2.5398 0 Td
(diagnosis)Tj
3.9571 0 Td
(was)Tj
-35.206 -1.3039 Td
(determined)Tj
4.8472 0 Td
(by)Tj
1.1848 0 Td
(a)Tj
0.652 0 Td
(specialist)Tj
3.8211 0 Td
(physician)Tj
4.0195 0 Td
(in)Tj
1.0375 0 Td
(physical)Tj
3.4525 0 Td
(medicine)Tj
3.9175 0 Td
(and)Tj
1.7291 0 Td
(rehabilitation)Tj
5.6182 0 Td
(and)Tj
1.7292 0 Td
(an)Tj
1.2018 0 Td
(expert)Tj
2.7213 0 Td
(in)Tj
-35.9317 -1.2983 Td
(pain)Tj
1.9842 0 Td
(management,)Tj
5.6636 0 Td
(according)Tj
4.1839 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(Budapest)Tj
3.8891 0 Td
(Research)Tj
3.804 0 Td
(Criteria)Tj
3.3166 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.6044 0 Td
(These)Tj
2.5625 0 Td
(criteria)Tj
3.0784 0 Td
(include)Tj
3.1861 0 Td
(con-)Tj
-35.7673 -1.2982 Td
(tinuous)Tj
3.2541 0 Td
(pain)Tj
1.9899 0 Td
(that)Tj
1.7802 0 Td
(is)Tj
0.8447 0 Td
(disproportionate)Tj
6.9448 0 Td
(to)Tj
1.0262 0 Td
(any)Tj
1.6554 0 Td
(inciting)Tj
3.3051 0 Td
(event,)Tj
2.5966 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.652 0 Td
(report)Tj
2.7099 0 Td
(of)Tj
1.0148 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9842 0 Td
(one)Tj
1.6951 0 Td
(symp-)Tj
-34.1345 -1.3039 Td
(tom)Tj
1.8425 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(following)Tj
3.9798 0 Td
(categories)Tj
4.1952 0 Td
(\(sensory,)Tj
3.8098 0 Td
(vasomotor,)Tj
4.7055 0 Td
(sudomotor,)Tj
4.8755 0 Td
(and)Tj
1.7291 0 Td
(motor/trophic\).)Tj
-27.6432 -1.2983 Td
(Furthermore,)Tj
5.6125 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9843 0 Td
(one)Tj
1.7008 0 Td
(sign)Tj
1.8595 0 Td
(had)Tj
1.7121 0 Td
(to)Tj
1.0205 0 Td
(be)Tj
1.1508 0 Td
(present)Tj
3.1635 0 Td
(in)Tj
1.0374 0 Td
(2)Tj
0.6974 0 Td
(or)Tj
1.0941 0 Td
(more)Tj
2.3414 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(categories)Tj
4.1896 0 Td
(\(sensory,)Tj
3.8154 0 Td
(vaso-)Tj
-34.8205 -1.2983 Td
(motor,)Tj
2.948 0 Td
(sudomotor,)Tj
4.8699 0 Td
(and)Tj
1.7291 0 Td
(motor/trophic\))Tj
6.3099 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(examination,)Tj
5.4538 0 Td
(without)Tj
3.3336 0 Td
(having)Tj
2.914 0 Td
(any)Tj
1.6611 0 Td
(other)Tj
-34.6845 -1.3039 Td
(condition)Tj
4.1102 0 Td
(that)Tj
1.7801 0 Td
(could)Tj
2.4491 0 Td
(account)Tj
3.3789 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(signs)Tj
2.2224 0 Td
(and)Tj
1.7234 0 Td
(symptoms)Tj
4.3597 0 Td
(encountered.)Tj
5.4652 0 Td
(The)Tj
1.7801 0 Td
(Budapest)Tj
3.8891 0 Td
(Research)Tj
-34.0098 -1.2983 Td
(Criteria)Tj
3.3165 0 Td
(have)Tj
2.0579 0 Td
(a)Tj
0.652 0 Td
(sensitivity)Tj
4.2236 0 Td
(of)Tj
1.0148 0 Td
(.78)Tj
1.3946 0 Td
(and)Tj
1.7348 0 Td
(a)Tj
0.652 0 Td
(specificity)Tj
4.2122 0 Td
(of)Tj
1.0148 0 Td
(.79)Tj
1.3946 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(diagnosis)Tj
3.9572 0 Td
(of)Tj
1.0148 0 Td
(CRPS)Tj
2.5398 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
-30.8407 -1.2982 Td
(The)Tj
1.7858 0 Td
(participants)Tj
4.9549 0 Td
(without)Tj
3.3335 0 Td
(CRPS)Tj
2.5399 0 Td
(were)Tj
2.1203 0 Td
(healthy)Tj
3.1351 0 Td
(adult)Tj
2.2507 0 Td
(volunteers,)Tj
4.6091 0 Td
(henceforth)Tj
4.558 0 Td
(the)Tj
1.4684 0 Td
(control)Tj
-31.9519 -1.2983 Td
(group,)Tj
2.8346 0 Td
(who)Tj
1.9389 0 Td
(were)Tj
2.1203 0 Td
(recruited)Tj
3.8551 0 Td
(by)Tj
1.1792 0 Td
(convenience)Tj
5.2157 0 Td
(and)Tj
1.7291 0 Td
(snowball)Tj
3.753 0 Td
(sampling.)Tj
4.1046 0 Td
(They)Tj
2.2393 0 Td
(were)Tj
2.1203 0 Td
(comprised)Tj
4.4391 0 Td
(of)Tj
-35.5292 -1.3039 Td
(48.5%)Tj
2.6305 0 Td
(university)Tj
4.1896 0 Td
(students)Tj
3.5659 0 Td
(while)Tj
2.3698 0 Td
(the)Tj
1.4683 0 Td
(rest)Tj
1.6781 0 Td
(were)Tj
2.1203 0 Td
(mainly)Tj
2.9934 0 Td
(employed)Tj
4.1385 0 Td
(individuals)Tj
4.6488 0 Td
(recruited)Tj
3.8551 0 Td
(off)Tj
-33.6583 -1.2983 Td
(campus.)Tj
1.1962 -1.2982 Td
(Exclusion)Tj
4.1385 0 Td
(criteria)Tj
3.0784 0 Td
(for)Tj
1.3833 0 Td
(both)Tj
2.058 0 Td
(groups)Tj
2.9707 0 Td
(included)Tj
3.7133 0 Td
(pregnancy;)Tj
4.6318 0 Td
(current)Tj
3.1861 0 Td
(or)Tj
1.0942 0 Td
(history)Tj
3.0104 0 Td
(of)Tj
1.0148 0 Td
(any)Tj
1.6554 0 Td
(neurologi-)Tj
-33.1311 -1.3039 Td
(cal)Tj
1.3209 0 Td
(disorder,)Tj
3.8041 0 Td
(including)Tj
4.0421 0 Td
(speech,)Tj
3.1181 0 Td
(vision,)Tj
2.8517 0 Td
(hearing)Tj
3.2598 0 Td
(or)Tj
1.0998 0 Td
(behavioral)Tj
4.388 0 Td
(abnormalities;)Tj
5.9301 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(presence)Tj
3.7134 0 Td
(of)Tj
-36.7311 -1.2983 Td
(a)Tj
0.6519 0 Td
(cognitive)Tj
3.8778 0 Td
(impairment)Tj
4.9833 0 Td
(or)Tj
1.0998 0 Td
(any)Tj
1.6554 0 Td
(other)Tj
2.3471 0 Td
(factor)Tj
2.5455 0 Td
(resulting)Tj
3.7304 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(inability)Tj
3.5149 0 Td
(to)Tj
1.0205 0 Td
(understand)Tj
4.7905 0 Td
(and/or)Tj
2.9367 0 Td
(to)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 472.2519 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(SMD)Tj
2.4165 0 Td
(is)Tj
0.9213 0 Td
(associated)Tj
4.9181 0 Td
(with)Tj
1.963 0 Td
(CRPS)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02013)Tj
4.089 0 Td
(54)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(9,)Tj
1.0418 0 Td
(2018)Tj
34.5758 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
118 0 obj
<>stream
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
endstream
endobj
121 0 obj
<>stream
endstream
endobj
122 0 obj
<>stream
endstream
endobj
123 0 obj
<>stream
endstream
endobj
124 0 obj
<>stream
endstream
endobj
125 0 obj
<>stream
endstream
endobj
126 0 obj
<>stream
endstream
endobj
127 0 obj
<>stream
endstream
endobj
128 0 obj
<>stream
endstream
endobj
129 0 obj
<>stream
endstream
endobj
130 0 obj
<>stream
endstream
endobj
131 0 obj
<>stream
endstream
endobj
132 0 obj
<>stream
endstream
endobj
133 0 obj
<>stream
endstream
endobj
134 0 obj
<>stream
endstream
endobj
135 0 obj
<>stream
endstream
endobj
136 0 obj
<>stream
endstream
endobj
137 0 obj
<>stream
endstream
endobj
138 0 obj
<>stream
endstream
endobj
139 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
140 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 144 0 R/Contents 145 0 R/TrimBox[0 0 612 792]>>
endobj
144 0 obj
[146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R 152 0 R 153 0 R 154 0 R 155 0 R]
endobj
146 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref044)>>
endobj
147 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref044)>>
endobj
148 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref045)>>
endobj
149 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref044)>>
endobj
150 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref046)>>
endobj
151 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref001)>>
endobj
152 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref001)>>
endobj
153 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref046)>>
endobj
154 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref001)>>
endobj
155 0 obj
<>/Border[0 0 0]/A 156 0 R>>
endobj
156 0 obj
<>
endobj
145 0 obj
[157 0 R 158 0 R 159 0 R 160 0 R 161 0 R 162 0 R 163 0 R]
endobj
157 0 obj
<>stream
q
0.83 0.64 0.02 0 k
495.0425 582.6331 m
504.5102 582.6331 l
h
f*
343.1622 556.611 m
352.6299 556.611 l
h
f*
357.052 556.611 m
366.5197 556.611 l
h
f*
530.6457 439.5969 m
540.0567 439.5969 l
h
f*
376.8378 322.6394 m
386.3622 322.6394 l
h
f*
317.3102 283.6346 m
322.0724 283.6346 l
h
f*
226.4882 218.6079 m
231.1937 218.6079 l
h
f*
312.6047 179.6031 m
322.0724 179.6031 l
h
f*
433.4173 94.9039 m
438.1795 94.9039 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(complete)Tj
3.8777 0 Td
(self-report)Tj
4.3767 0 Td
(questionnaires.)Tj
6.2929 0 Td
(Exclusion)Tj
4.1328 0 Td
(criterion)Tj
3.7021 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(study)Tj
2.3924 0 Td
(group)Tj
2.6079 0 Td
(also)Tj
1.7688 0 Td
(included)Tj
3.7134 0 Td
(pain)Tj
-35.7163 -1.3039 Td
(disorder)Tj
3.5773 0 Td
(other)Tj
2.347 0 Td
(than)Tj
2.0296 0 Td
(CRPS.)Tj
2.7609 0 Td
(Additional)Tj
4.5298 0 Td
(exclusion)Tj
3.9911 0 Td
(criteria)Tj
3.0728 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(control)Tj
3.1237 0 Td
(group)Tj
2.6079 0 Td
(included)Tj
3.7134 0 Td
(any)Tj
-34.6108 -1.2982 Td
(pain)Tj
1.9842 0 Td
(disorder,)Tj
3.8041 0 Td
(a)Tj
0.6519 0 Td
(family)Tj
2.7326 0 Td
(history)Tj
3.0047 0 Td
(of)Tj
1.0148 0 Td
(siblings,)Tj
3.4696 0 Td
(parents,)Tj
3.4015 0 Td
(and/or)Tj
2.9367 0 Td
(grandparents)Tj
5.5219 0 Td
(that)Tj
1.7745 0 Td
(included)Tj
3.7133 0 Td
(any)Tj
-34.0098 -1.2983 Td
(form)Tj
2.2053 0 Td
(of)Tj
1.0148 0 Td
(psychopathology.)Tj
-2.0239 -1.2983 Td
(The)Tj
1.7858 0 Td
(research)Tj
3.5546 0 Td
(was)Tj
1.7008 0 Td
(approved)Tj
3.9741 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4684 0 Td
(Reuth)Tj
2.6192 0 Td
(Rehabilitation)Tj
5.8676 0 Td
(Hospital)Tj
3.617 0 Td
(review)Tj
2.846 0 Td
(board,)Tj
2.7949 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
-34.333 -1.3039 Td
(study)Tj
2.381 0 Td
(protocol)Tj
3.5943 0 Td
(conformed)Tj
4.6318 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.4683 0 Td
(ethical)Tj
2.8347 0 Td
(guidelines)Tj
4.2746 0 Td
(of)Tj
1.0091 0 Td
(the)Tj
1.4627 0 Td
(1975)Tj
2.1203 0 Td
(Declaration)Tj
4.9039 0 Td
(of)Tj
1.0091 0 Td
(Helsinki.)Tj
3.8211 0 Td
(All)Tj
1.389 0 Td
(par-)Tj
-35.9204 -1.2982 Td
(ticipants)Tj
3.6339 0 Td
(provided)Tj
3.8155 0 Td
(written)Tj
3.1124 0 Td
(consent)Tj
3.3278 0 Td
(before)Tj
2.7439 0 Td
(enrolling)Tj
3.8438 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(study.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 600.7181 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(2.2)Tj
1.4598 0 Td
(Measures)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 211.9748 583.7102 cm
BT
/F12 1 Tf
1 TL
-0.007 Tc
0 0 Td
(2.2.1)Tj
2.1883 0 Td
(The)Tj
1.8312 0 Td
(Sensory)Tj
3.4582 0 Td
(Responsiveness)Tj
6.5933 0 Td
(QuestionnaireIntensit)Tj
10.097 0 Td
(y)Tj
0.6803 0 Td
(Scale.)Tj
/F8 1 Tf
3.1238 0 Td
([)Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(])Tj
1.8368 0 Td
(is)Tj
0.839 0 Td
(a)Tj
0.652 0 Td
(standardized)Tj
-32.4961 -1.2982 Td
(reliable)Tj
3.1124 0 Td
(and)Tj
1.7234 0 Td
(valid)Tj
2.1317 0 Td
(self-report)Tj
4.3483 0 Td
(questionnaire,)Tj
5.8847 0 Td
(assessing)Tj
3.7757 0 Td
(responses)Tj
4.0705 0 Td
(to)Tj
1.0148 0 Td
(daily)Tj
2.1373 0 Td
(sensations)Tj
4.2973 0 Td
(and)Tj
1.7235 0 Td
(is)Tj
0.839 0 Td
(used)Tj
-35.0586 -1.3039 Td
(to)Tj
1.0205 0 Td
(clinically)Tj
3.7473 0 Td
(identify)Tj
3.2655 0 Td
(SMD)Tj
2.3187 0 Td
(in)Tj
1.0318 0 Td
(adults)Tj
2.5965 0 Td
([)Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7235 0 Td
(45)Tj
0 g
(].)Tj
1.7234 0 Td
(The)Tj
1.7745 0 Td
(Sensory)Tj
3.3392 0 Td
(Responsiveness)Tj
6.3552 0 Td
(Questionnaire)Tj
-28.8961 -1.2983 Td
(Intensity)Tj
3.7303 0 Td
(Scale)Tj
2.211 0 Td
(is)Tj
0.8391 0 Td
(comprised)Tj
4.4106 0 Td
(of)Tj
1.0092 0 Td
(a)Tj
0.6519 0 Td
(set)Tj
1.2926 0 Td
(of)Tj
1.0092 0 Td
(58)Tj
1.1678 0 Td
(items)Tj
2.3754 0 Td
(representing)Tj
5.1987 0 Td
(typical)Tj
2.8403 0 Td
(scenarios)Tj
3.8892 0 Td
(occasionally)Tj
-30.6253 -1.2983 Td
(occuring)Tj
3.7303 0 Td
(throughout)Tj
4.7452 0 Td
(daily)Tj
2.1373 0 Td
(life.)Tj
1.6554 0 Td
(Each)Tj
2.16 0 Td
(item)Tj
2.0182 0 Td
(consists)Tj
3.3222 0 Td
(of)Tj
1.0092 0 Td
(one)Tj
1.6894 0 Td
(sensory)Tj
3.2258 0 Td
(stimulus)Tj
3.6057 0 Td
(in)Tj
1.0318 0 Td
(one)Tj
1.6894 0 Td
(modality)Tj
-32.0199 -1.3039 Td
(including)Tj
4.0138 0 Td
(somatosensory,)Tj
6.3552 0 Td
(olfactory,)Tj
3.9458 0 Td
(gustatory,)Tj
4.1329 0 Td
(vestibular,)Tj
4.303 0 Td
(auditory)Tj
3.5829 0 Td
(and)Tj
1.7235 0 Td
(visual)Tj
2.4945 0 Td
(stimuli)Tj
2.982 0 Td
(\(exclud-)Tj
-33.5336 -1.2982 Td
(ing)Tj
1.491 0 Td
(pain\).)Tj
2.5341 0 Td
(The)Tj
1.7745 0 Td
(items)Tj
2.3754 0 Td
(are)Tj
1.44 0 Td
(worded)Tj
3.2428 0 Td
(in)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(manner)Tj
3.3505 0 Td
(attributing)Tj
4.4674 0 Td
(an)Tj
1.1962 0 Td
(aversive)Tj
3.3846 0 Td
(/hedonic)Tj
3.753 0 Td
(valence)Tj
3.1521 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
-34.8602 -1.2983 Td
(scenarios)Tj
3.889 0 Td
(\(e.g.)Tj
/F13 1 Tf
1.8822 0 Td
[()]TJ
0.55 0 Td
[()2()18()3()12()]TJ
2.279 0 Td
[()3()7()16( )-9(\n)12()13()]TJ
3.3108 0 Td
[()3()4()10()4()2()]TJ
2.9481 0 Td
[(\r)13()4()12()10()6()8()]TJ
2.8006 0 Td
[()11()]TJ
1.2075 0 Td
[()24()2()-3()15()12()]TJ
/F8 1 Tf
(\).)Tj
3.1975 0 Td
(Using)Tj
2.5852 0 Td
(a)Tj
0.6463 0 Td
(5-point)Tj
3.1634 0 Td
(scale,)Tj
2.3187 0 Td
(participants)Tj
4.9209 0 Td
(rate)Tj
-35.6992 -1.3039 Td
(the)Tj
1.4569 0 Td
(intensity)Tj
3.6624 0 Td
(of)Tj
1.0091 0 Td
(the)Tj
1.4627 0 Td
(aversive)Tj
3.3845 0 Td
(/hedonic)Tj
3.7474 0 Td
(response)Tj
3.7134 0 Td
(to)Tj
1.0148 0 Td
(the)Tj
1.4626 0 Td
(scenarios,)Tj
4.1102 0 Td
(with)Tj
1.9899 0 Td
(the)Tj
1.457 0 Td
(anchors)Tj
3.3732 0 Td
(`)Tj
/F13 1 Tf
[()6()12()]TJ
1.7235 0 Td
[()22()]TJ
0.9978 0 Td
[()11()4()59()]TJ
/F8 1 Tf
1.3719 0 Td
(\(1\))Tj
-35.9373 -1.2983 Td
(to)Tj
/F13 1 Tf
1.0205 0 Td
[()12()3()2( )-20()]TJ
2.0295 0 Td
[()18()4(\r)13()91()]TJ
/F8 1 Tf
2.5908 0 Td
(\(5\).)Tj
1.5874 0 Td
(The)Tj
1.7745 0 Td
(Sensory)Tj
3.3449 0 Td
(Responsiveness)Tj
6.3552 0 Td
(QuestionnaireIntensity)Tj
10.3407 0 Td
(Scale)Tj
2.2054 0 Td
(has)Tj
1.5363 0 Td
(been)Tj
2.109 0 Td
(dem-)Tj
-34.8942 -1.2983 Td
(onstrated)Tj
3.9627 0 Td
(to)Tj
1.0205 0 Td
(have)Tj
2.0466 0 Td
(an)Tj
1.1962 0 Td
(internal)Tj
3.3335 0 Td
(consistency)Tj
4.8019 0 Td
(\(Cronbach)Tj
/F6 1 Tf
4.5184 0 Td
()Tj
/F8 1 Tf
0.7824 0 Td
(=)Tj
0.7993 0 Td
(0.900.93\))Tj
4.354 0 Td
(and)Tj
1.7178 0 Td
(test-retest)Tj
4.0932 0 Td
(reliability)Tj
-32.6265 -1.3039 Td
(\(r)Tj
0.9241 0 Td
(=)Tj
0.7993 0 Td
(0.710.84;)Tj
/F13 1 Tf
4.2349 0 Td
[()]TJ
/F14 1 Tf
0 Tc
0.6917 0 Td
(<)Tj
/F8 1 Tf
-0.007 Tc
0.9921 0 Td
(0.0010.005\))Tj
5.2951 0 Td
(as)Tj
1.0091 0 Td
(well)Tj
1.8085 0 Td
(as)Tj
1.0091 0 Td
(content,)Tj
3.4696 0 Td
(construct)Tj
3.9515 0 Td
(and)Tj
1.7234 0 Td
(criterion)Tj
3.668 0 Td
(validity)Tj
3.1465 0 Td
([)Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(].)Tj
-0.004 Tc
-31.5267 -1.2982 Td
(In)Tj
1.1111 0 Td
(this)Tj
1.6725 0 Td
(study,)Tj
2.6192 0 Td
(sensory)Tj
3.2428 0 Td
(over-responsiveness)Tj
8.2601 0 Td
(SOR)Tj
2.0636 0 Td
(sub-type)Tj
3.6566 0 Td
(was)Tj
1.7008 0 Td
(determined)Tj
4.8529 0 Td
(by)Tj
1.1792 0 Td
(applying)Tj
3.668 0 Td
(the)Tj
-35.223 -1.2983 Td
(Sensory)Tj
3.3618 0 Td
(Responsiveness)Tj
6.3949 0 Td
(QuestionnaireInt)Tj
7.8406 0 Td
(ensity)Tj
2.5682 0 Td
(ScaleAversive)Tj
6.5877 0 Td
(sub-score)Tj
4.0535 0 Td
(\(32)Tj
1.5137 0 Td
(items\),)Tj
2.9536 0 Td
(in)Tj
-35.274 -1.2983 Td
(which)Tj
2.6475 0 Td
(scores)Tj
2.6702 0 Td
(were)Tj
2.1203 0 Td
(2)Tj
0.6973 0 Td
(standard)Tj
3.7191 0 Td
(deviations)Tj
4.3086 0 Td
(above)Tj
2.5511 0 Td
(the)Tj
1.4684 0 Td
(mean)Tj
2.4434 0 Td
(cut-off)Tj
2.9027 0 Td
(score)Tj
2.3074 0 Td
(\(1.87)Tj
/F12 1 Tf
2.211 0 Td
(+)Tj
/F8 1 Tf
0.788 0 Td
(0.52\))Tj
2.2167 0 Td
(for)Tj
1.3833 0 Td
(normal)Tj
-34.435 -1.3039 Td
(responsiveness.)Tj
6.3722 0 Td
(Sensory)Tj
3.3618 0 Td
(under-responsiveness)Tj
8.9008 0 Td
(sub-type)Tj
3.6567 0 Td
(was)Tj
1.7007 0 Td
(determined)Tj
4.8529 0 Td
(applying)Tj
3.668 0 Td
(the)Tj
1.4684 0 Td
(Sensory)Tj
-33.9815 -1.2982 Td
(Responsiveness)Tj
6.4005 0 Td
(QuestionnaireIntensity)Tj
10.4031 0 Td
(ScaleHedonic)Tj
6.616 0 Td
(sub-score)Tj
4.0479 0 Td
(\(26)Tj
1.5137 0 Td
(items\),)Tj
2.9537 0 Td
(for)Tj
1.3889 0 Td
(which)Tj
-33.3238 -1.2983 Td
(scores)Tj
2.6645 0 Td
(were)Tj
2.126 0 Td
(above)Tj
2.5455 0 Td
(the)Tj
1.4683 0 Td
(mean)Tj
2.4434 0 Td
(cut-off)Tj
2.9027 0 Td
(score)Tj
2.3074 0 Td
(+2SD)Tj
2.4888 0 Td
(\(2.10)Tj
/F12 1 Tf
2.211 0 Td
(+)Tj
/F8 1 Tf
0.788 0 Td
(0.66\))Tj
2.2167 0 Td
(for)Tj
1.3833 0 Td
(normal)Tj
3.1464 0 Td
(responsiveness.)Tj
6.378 0 Td
(Par-)Tj
-35.07 -1.3039 Td
(ticipants)Tj
3.6339 0 Td
(scoring)Tj
3.1635 0 Td
(higher)Tj
2.8006 0 Td
(than)Tj
2.0296 0 Td
(one)Tj
1.7008 0 Td
(or)Tj
1.0998 0 Td
(both)Tj
2.0579 0 Td
(cut-off)Tj
2.9027 0 Td
(scores)Tj
2.6645 0 Td
(comprised)Tj
4.4391 0 Td
(the)Tj
1.4683 0 Td
(SMD)Tj
2.3301 0 Td
(group.)Tj
2.8289 0 Td
(A)Tj
0.9071 0 Td
(mean+2)Tj
-34.0268 -1.2983 Td
(SD)Tj
1.4286 0 Td
(cut-off)Tj
2.9026 0 Td
(score)Tj
2.3074 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.058 0 Td
(to)Tj
1.0261 0 Td
(ensure)Tj
2.8743 0 Td
(cautious)Tj
3.566 0 Td
(estimation)Tj
4.4447 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(SMD)Tj
2.3244 0 Td
(prevalence.)Tj
/F12 1 Tf
-25.9255 -1.2983 Td
(2.2.2)Tj
2.2053 0 Td
(The)Tj
1.8425 0 Td
(CRPS)Tj
2.6475 0 Td
(Severity)Tj
3.5433 0 Td
(Score)Tj
2.4945 0 Td
(\(CSS\).)Tj
/F8 1 Tf
3.4129 0 Td
([)Tj
0.83 0.64 0.02 0 k
(46)Tj
0 g
(],)Tj
2.0749 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(standard)Tj
3.7247 0 Td
(score)Tj
2.3074 0 Td
(which)Tj
2.6475 0 Td
(provides)Tj
3.651 0 Td
(a)Tj
0.652 0 Td
(continu-)Tj
-33.9021 -1.3039 Td
(ous)Tj
1.6157 0 Td
(type)Tj
1.9105 0 Td
(quantitative)Tj
4.9833 0 Td
(index)Tj
2.4491 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(CRPS)Tj
2.5399 0 Td
(signs)Tj
2.2223 0 Td
(and)Tj
1.7348 0 Td
(symptom)Tj
3.9968 0 Td
(severity)Tj
3.2712 0 Td
(as)Tj
1.0148 0 Td
(they)Tj
1.9275 0 Td
(are)Tj
1.4457 0 Td
(identified)Tj
4.0592 0 Td
(by)Tj
-35.6539 -1.2982 Td
(current)Tj
3.1804 0 Td
(diagnostic)Tj
4.32 0 Td
(criteria.)Tj
3.3051 0 Td
(CRPS)Tj
2.5399 0 Td
(diagnosis)Tj
3.9571 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(Budapest)Tj
3.8891 0 Td
(criteria)Tj
3.0784 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(dichotomous)Tj
-30.9881 -1.2983 Td
(\(yes/no\))Tj
3.5205 0 Td
(diagnostic)Tj
4.32 0 Td
(decision)Tj
3.549 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(],)Tj
1.5987 0 Td
(and)Tj
1.7291 0 Td
(does)Tj
2.041 0 Td
(not)Tj
1.576 0 Td
(provide)Tj
3.2882 0 Td
(information)Tj
5.074 0 Td
(of)Tj
1.0148 0 Td
(individual)Tj
4.2916 0 Td
(clinical)Tj
3.0727 0 Td
(pre-)Tj
-35.0756 -1.3039 Td
(sentation)Tj
3.9061 0 Td
(differences,)Tj
4.7905 0 Td
(severity,)Tj
3.4979 0 Td
(or)Tj
1.0998 0 Td
(liability)Tj
3.2088 0 Td
(of)Tj
1.0148 0 Td
(CRPS)Tj
2.5399 0 Td
(signs)Tj
2.2223 0 Td
(and)Tj
1.7291 0 Td
(symptoms.)Tj
4.5808 0 Td
(The)Tj
1.7858 0 Td
(CRPS)Tj
2.5398 0 Td
(Severity)Tj
-32.9156 -1.2983 Td
(Score)Tj
2.4207 0 Td
(comprises)Tj
4.269 0 Td
(17)Tj
1.1735 0 Td
(items)Tj
2.3868 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4741 0 Td
(Budapest)Tj
3.8891 0 Td
(criteria)Tj
3.0727 0 Td
(\(8)Tj
1.0375 0 Td
(self-reported)Tj
5.3291 0 Td
(symptoms)Tj
4.3596 0 Td
(and)Tj
1.7292 0 Td
(9)Tj
0.6973 0 Td
(signs)Tj
-32.8533 -1.2983 Td
(observed)Tj
3.7927 0 Td
(on)Tj
1.2756 0 Td
(examination)Tj
5.2327 0 Td
(by)Tj
1.1848 0 Td
(a)Tj
0.652 0 Td
(clinician\).)Tj
4.2123 0 Td
(Each)Tj
2.1713 0 Td
(present)Tj
3.1634 0 Td
(sign/symptom)Tj
5.9698 0 Td
(is)Tj
0.8504 0 Td
(counted)Tj
3.4752 0 Td
(as)Tj
1.0148 0 Td
(one)Tj
1.7008 0 Td
(point)Tj
-34.6958 -1.2982 Td
(and)Tj
1.7291 0 Td
(added)Tj
2.6588 0 Td
(to)Tj
1.0262 0 Td
(a)Tj
0.6519 0 Td
(total)Tj
2.007 0 Td
(score,)Tj
2.5284 0 Td
(ranging)Tj
3.3222 0 Td
(from)Tj
2.2054 0 Td
(0)Tj
0.6973 0 Td
(to)Tj
1.0261 0 Td
(17,)Tj
1.3947 0 Td
(which)Tj
2.6532 0 Td
(constitutes)Tj
4.5297 0 Td
(the)Tj
1.474 0 Td
(CRPS)Tj
2.5398 0 Td
(Severity)Tj
3.3846 0 Td
(Score)Tj
-33.8284 -1.3039 Td
(score)Tj
2.3073 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5988 0 Td
(Higher)Tj
3.0443 0 Td
(scores)Tj
2.6646 0 Td
(indicate)Tj
3.4129 0 Td
(greater)Tj
3.0047 0 Td
(CRPS)Tj
2.5398 0 Td
(severity.)Tj
3.4979 0 Td
(The)Tj
1.7859 0 Td
(CRPS)Tj
2.5398 0 Td
(Severity)Tj
3.3845 0 Td
(Score)Tj
2.4208 0 Td
(has)Tj
1.542 0 Td
(been)Tj
-33.7433 -1.2983 Td
(shown)Tj
2.8459 0 Td
(to)Tj
1.0261 0 Td
(have)Tj
2.058 0 Td
(high)Tj
2.0126 0 Td
(internal)Tj
3.3562 0 Td
(consistency,)Tj
5.0626 0 Td
(discriminate)Tj
5.2271 0 Td
(validity,)Tj
3.3958 0 Td
(and)Tj
1.7292 0 Td
(strong)Tj
2.7722 0 Td
(association)Tj
4.6261 0 Td
(with)Tj
-34.1118 -1.2983 Td
(both)Tj
2.0579 0 Td
(the)Tj
1.4683 0 Td
(current)Tj
3.1861 0 Td
(International)Tj
5.4879 0 Td
(Association)Tj
4.8755 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(Study)Tj
2.5059 0 Td
(of)Tj
1.0147 0 Td
(Pain)Tj
2.024 0 Td
(diagnostic)Tj
4.3199 0 Td
(criteria)Tj
3.0785 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
-34.6051 -1.3039 Td
(proposed)Tj
3.9514 0 Td
(Budapest)Tj
3.8891 0 Td
(criteria)Tj
3.0784 0 Td
([)Tj
0.83 0.64 0.02 0 k
(46)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 151.9937 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(2.3)Tj
1.4598 0 Td
(Procedure)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 134.9858 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Participants)Tj
5.0002 0 Td
(were)Tj
2.1203 0 Td
(contacted)Tj
4.1046 0 Td
(by)Tj
1.1792 0 Td
(phone,)Tj
2.9707 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(study's)Tj
2.965 0 Td
(purpose)Tj
3.4413 0 Td
(and)Tj
1.7348 0 Td
(other)Tj
2.347 0 Td
(preliminary)Tj
4.9379 0 Td
(informa-)Tj
-34.0041 -1.2982 Td
(tion)Tj
1.8425 0 Td
(were)Tj
2.1203 0 Td
(provided)Tj
3.8154 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(researcher)Tj
4.3483 0 Td
(while)Tj
2.3697 0 Td
(exclusion)Tj
3.9912 0 Td
(criteria)Tj
3.0727 0 Td
(were)Tj
2.126 0 Td
(verified.)Tj
3.4639 0 Td
(For)Tj
1.6271 0 Td
(participants)Tj
4.9606 0 Td
(in)Tj
-36.3909 -1.2983 Td
(the)Tj
1.4683 0 Td
(CRPS)Tj
2.5398 0 Td
(group,)Tj
2.8346 0 Td
(the)Tj
1.4684 0 Td
(physician)Tj
4.0195 0 Td
(conducted)Tj
4.4277 0 Td
(an)Tj
1.2019 0 Td
(on-site)Tj
2.9763 0 Td
(evaluation)Tj
4.3653 0 Td
(using)Tj
2.3868 0 Td
(the)Tj
1.4683 0 Td
(diagnostic)Tj
4.32 0 Td
(signs)Tj
2.2224 0 Td
(and)Tj
-35.6993 -1.3039 Td
(symptoms)Tj
4.3596 0 Td
(of)Tj
1.0148 0 Td
(CRPS,)Tj
2.7609 0 Td
(permitting)Tj
4.4958 0 Td
(the)Tj
1.474 0 Td
(calculation)Tj
4.575 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(CSS)Tj
1.8368 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5988 0 Td
(After)Tj
2.2847 0 Td
(CRPS)Tj
2.5398 0 Td
(diagnosis)Tj
3.9571 0 Td
(was)Tj
1.7008 0 Td
(con-)Tj
-35.0813 -1.2983 Td
(firmed,)Tj
3.1407 0 Td
(subjects)Tj
3.3789 0 Td
(were)Tj
2.1203 0 Td
(asked)Tj
2.4661 0 Td
(to)Tj
1.0262 0 Td
(complete)Tj
3.8777 0 Td
(a)Tj
0.652 0 Td
(medical)Tj
3.3619 0 Td
(and)Tj
1.7291 0 Td
(demographic)Tj
5.5048 0 Td
(questionnaire)Tj
5.7033 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8255 0 Td
(as)Tj
ET
Q
q
1 j
1 J
0 w
381.0331 430.3559 m
399.4583 430.3559 l
399.4583 430.0724 l
381.0331 430.0724 l
f*
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 472.2519 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(SMD)Tj
2.4165 0 Td
(is)Tj
0.9213 0 Td
(associated)Tj
4.9181 0 Td
(with)Tj
1.963 0 Td
(CRPS)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02013)Tj
4.089 0 Td
(54)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(9,)Tj
1.0418 0 Td
(2018)Tj
34.5758 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
158 0 obj
<>stream
endstream
endobj
159 0 obj
<>stream
endstream
endobj
160 0 obj
<>stream
endstream
endobj
161 0 obj
<>stream
endstream
endobj
162 0 obj
<>stream
endstream
endobj
163 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
164 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 166 0 R/Contents 167 0 R/TrimBox[0 0 612 792]>>
endobj
166 0 obj
[168 0 R 169 0 R 170 0 R 171 0 R 172 0 R]
endobj
168 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.ref044)>>
endobj
169 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.t001)>>
endobj
170 0 obj
<>/Border[0 0 0]/Dest(Lpone.0201354.t001)>>
endobj
171 0 obj
<>/Border[0 0 0]/A 173 0 R>>
endobj
173 0 obj
<>
endobj
172 0 obj
<>/Border[0 0 0]/A 174 0 R>>
endobj
174 0 obj
<>
endobj
167 0 obj
[175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R]
endobj
175 0 obj
<>stream
q
0.83 0.64 0.02 0 k
442.0346 706.337 m
451.5591 706.337 l
h
f*
200.0126 256.989 m
229.2094 256.989 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(the)Tj
1.4683 0 Td
(Sensory)Tj
3.3619 0 Td
(Responsiveness)Tj
6.4005 0 Td
(QuestionnaireIntensity)Tj
10.4088 0 Td
(Scale)Tj
2.2223 0 Td
([)Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(].)Tj
2.075 0 Td
(This)Tj
1.9899 0 Td
(evaluation)Tj
4.3597 0 Td
(meeting)Tj
-32.2864 -1.3039 Td
(lasted)Tj
2.5114 0 Td
(for)Tj
1.3833 0 Td
(approximately)Tj
5.9754 0 Td
(one)Tj
1.7008 0 Td
(hour.)Tj
2.3811 0 Td
(As)Tj
1.2642 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(control)Tj
3.1237 0 Td
(group,)Tj
2.8347 0 Td
(participants)Tj
4.9549 0 Td
(met)Tj
1.7631 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
-32.7399 -1.2982 Td
(researcher)Tj
4.3483 0 Td
(and)Tj
1.7291 0 Td
(completed)Tj
4.4107 0 Td
(a)Tj
0.6519 0 Td
(medical)Tj
3.3619 0 Td
(and)Tj
1.7291 0 Td
(demographic)Tj
5.5049 0 Td
(questionnaire)Tj
5.7032 0 Td
(followed)Tj
3.651 0 Td
(by)Tj
1.1793 0 Td
(the)Tj
1.474 0 Td
(Sensory)Tj
-33.7434 -1.2983 Td
(Responsiveness)Tj
6.4005 0 Td
(QuestionnaireIntensity)Tj
10.4031 0 Td
(Scale.)Tj
2.4491 0 Td
(This)Tj
1.99 0 Td
(session)Tj
3.05 0 Td
(lasted)Tj
2.5058 0 Td
(for)Tj
1.389 0 Td
(approximately)Tj
5.9754 0 Td
(30)Tj
1.1735 0 Td
(min-)Tj
-35.3364 -1.2983 Td
(utes,)Tj
2.0522 0 Td
(while)Tj
2.3698 0 Td
(the)Tj
1.4683 0 Td
(researcher)Tj
4.354 0 Td
(was)Tj
1.7008 0 Td
(present)Tj
3.1634 0 Td
(and)Tj
1.7291 0 Td
(available)Tj
3.668 0 Td
(for)Tj
1.3833 0 Td
(participants')Tj
5.1704 0 Td
(queries.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 616.7622 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(2.4)Tj
1.4598 0 Td
(Data)Tj
2.2441 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 599.7543 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Statistical)Tj
4.0195 0 Td
(analyses)Tj
3.4865 0 Td
(were)Tj
2.1203 0 Td
(performed)Tj
4.4731 0 Td
(with)Tj
1.9956 0 Td
(SAS)Tj
1.8538 0 Td
(V9.3)Tj
2.092 0 Td
(\(SAS)Tj
2.194 0 Td
(Institute,)Tj
3.8097 0 Td
(Cary)Tj
2.143 0 Td
(NC,)Tj
1.8425 0 Td
(USA\).)Tj
2.6816 0 Td
(Continuous)Tj
-32.7116 -1.2982 Td
(variables)Tj
3.719 0 Td
(were)Tj
2.1203 0 Td
(summarized)Tj
5.1874 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(mean)Tj
2.4491 0 Td
(and)Tj
1.7291 0 Td
(standard)Tj
3.7247 0 Td
(deviation)Tj
3.9458 0 Td
(and)Tj
1.7292 0 Td
(compared)Tj
4.2462 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(t-test,)Tj
-34.1459 -1.3039 Td
(ANOVA)Tj
3.7643 0 Td
(or)Tj
1.0999 0 Td
(a)Tj
0.6519 0 Td
(non-parametric)Tj
6.5367 0 Td
(equivalent.)Tj
4.5751 0 Td
(Categorical)Tj
4.7508 0 Td
(variables)Tj
3.719 0 Td
(were)Tj
2.126 0 Td
(summarized)Tj
5.1817 0 Td
(by)Tj
1.1849 0 Td
(count)Tj
-33.5903 -1.2983 Td
(and)Tj
1.7291 0 Td
(percentage,)Tj
4.7735 0 Td
(and)Tj
1.7291 0 Td
(compared)Tj
4.2463 0 Td
(with)Tj
1.9956 0 Td
(Fisher's)Tj
3.2768 0 Td
(exact)Tj
2.262 0 Td
(test.)Tj
1.8255 0 Td
(All)Tj
1.4003 0 Td
(statistical)Tj
3.9061 0 Td
(tests)Tj
1.9616 0 Td
(were)Tj
2.126 0 Td
(two-sided)Tj
4.1669 0 Td
(and)Tj
-35.3988 -1.2983 Td
(tested)Tj
2.5511 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(5%)Tj
1.457 0 Td
(level)Tj
2.0126 0 Td
(of)Tj
1.0148 0 Td
(significance.)Tj
5.159 0 Td
(This)Tj
1.9899 0 Td
(is)Tj
0.8447 0 Td
(an)Tj
1.2076 0 Td
(exploratory)Tj
4.8132 0 Td
(study)Tj
2.3924 0 Td
(since)Tj
2.2394 0 Td
(previous)Tj
3.651 0 Td
(data)Tj
1.9162 0 Td
(between)Tj
-32.8533 -1.3039 Td
(SMD)Tj
2.3243 0 Td
(and)Tj
1.7292 0 Td
(CRPS)Tj
2.5398 0 Td
(does)Tj
2.0409 0 Td
(not)Tj
1.5704 0 Td
(exist,)Tj
2.262 0 Td
(thus)Tj
1.9333 0 Td
(nominal)Tj
3.5943 0 Td
(p-values)Tj
3.5319 0 Td
(were)Tj
2.126 0 Td
(presented,)Tj
4.337 0 Td
(without)Tj
3.3335 0 Td
(a)Tj
0.652 0 Td
(correction)Tj
4.3596 0 Td
(for)Tj
-36.3342 -1.2982 Td
(multiple)Tj
3.5659 0 Td
(testing.)Tj
3.1068 0 Td
(Logistic)Tj
3.3448 0 Td
(regression)Tj
4.32 0 Td
(modeling)Tj
4.0252 0 Td
(was)Tj
1.7007 0 Td
(performed)Tj
4.4674 0 Td
(to)Tj
1.0262 0 Td
(identify)Tj
3.2938 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
2.9026 0 Td
(for)Tj
1.389 0 Td
(CRPS)Tj
-34.8602 -1.2983 Td
(\(age,)Tj
2.1089 0 Td
(gender,)Tj
3.2031 0 Td
(SRQ)Tj
2.0637 0 Td
(scores,)Tj
2.8913 0 Td
(CRPS)Tj
2.5398 0 Td
(signs)Tj
2.2223 0 Td
(and)Tj
1.7292 0 Td
(symptoms)Tj
4.3596 0 Td
(\(CCS\)\).)Tj
3.2712 0 Td
(Variables)Tj
3.9571 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(significant)Tj
-33.1424 -1.3039 Td
(\(with)Tj
2.3357 0 Td
(p)Tj
/F14 1 Tf
0 Tc
(<)Tj
/F8 1 Tf
-0.004 Tc
(0.05\))Tj
3.5036 0 Td
(were)Tj
2.1203 0 Td
(entered)Tj
3.2371 0 Td
(into)Tj
1.8425 0 Td
(a)Tj
0.652 0 Td
(multivariate)Tj
5.0626 0 Td
(model.)Tj
2.9707 0 Td
(The)Tj
1.7802 0 Td
(variables)Tj
3.719 0 Td
(designated)Tj
4.4957 0 Td
(to)Tj
1.0262 0 Td
(remain)Tj
3.084 0 Td
(in)Tj
-35.8296 -1.2983 Td
(the)Tj
1.4683 0 Td
(model)Tj
2.7439 0 Td
(were)Tj
2.1203 0 Td
(those)Tj
2.3414 0 Td
(risk)Tj
1.7121 0 Td
(factors)Tj
2.9027 0 Td
(of)Tj
1.0148 0 Td
(CRPS)Tj
2.5398 0 Td
(which)Tj
2.6532 0 Td
(remained)Tj
4.0365 0 Td
(statistically)Tj
4.6091 0 Td
(significant)Tj
4.388 0 Td
(when)Tj
-32.5301 -1.2983 Td
(entered)Tj
3.2371 0 Td
(together)Tj
3.5319 0 Td
(and)Tj
1.7292 0 Td
(that)Tj
1.7801 0 Td
(maximized)Tj
4.6601 0 Td
(the)Tj
1.4684 0 Td
(predictive)Tj
4.1952 0 Td
(power)Tj
2.7213 0 Td
(\(area)Tj
2.2223 0 Td
(under)Tj
2.6192 0 Td
(the)Tj
1.4683 0 Td
(curve)Tj
2.4208 0 Td
([AUC])Tj
2.9877 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-36.0564 -1.2982 Td
(receiver)Tj
3.3675 0 Td
(operating)Tj
4.0422 0 Td
(characteristic)Tj
5.5332 0 Td
([ROC])Tj
2.9253 0 Td
(curve\))Tj
2.7496 0 Td
(of)Tj
1.0091 0 Td
(the)Tj
1.457 0 Td
(model,)Tj
2.9594 0 Td
(such)Tj
2.0522 0 Td
(that)Tj
1.7688 0 Td
(the)Tj
1.4627 0 Td
(AUC)Tj
2.2904 0 Td
(of)Tj
1.0091 0 Td
(the)Tj
1.457 0 Td
(resulting)Tj
-34.0835 -1.3039 Td
(ROC)Tj
2.2506 0 Td
(curve)Tj
2.4208 0 Td
(was)Tj
1.7008 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9786 0 Td
(0.8.)Tj
1.6214 0 Td
(The)Tj
1.7858 0 Td
(risk)Tj
1.7178 0 Td
(score,)Tj
2.5285 0 Td
(which)Tj
2.6532 0 Td
(was)Tj
1.6951 0 Td
(calculated)Tj
4.2066 0 Td
(from)Tj
2.2053 0 Td
(a)Tj
0.652 0 Td
(linear)Tj
2.5115 0 Td
(combination)Tj
5.3461 0 Td
(of)Tj
-36.2265 -1.2983 Td
(the)Tj
1.4683 0 Td
(logistic)Tj
3.0557 0 Td
(regression)Tj
4.32 0 Td
(model)Tj
2.7439 0 Td
(coefficients,)Tj
4.9606 0 Td
(is)Tj
0.8504 0 Td
(presented)Tj
4.1159 0 Td
(in)Tj
1.0374 0 Td
(a)Tj
0.652 0 Td
(figure,)Tj
2.7893 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(effect)Tj
2.364 0 Td
(plot,)Tj
2.0126 0 Td
(portraying)Tj
-32.5868 -1.2983 Td
(the)Tj
1.4683 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(having)Tj
2.914 0 Td
(CRPS)Tj
2.5398 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(function)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(SMD)Tj
2.3244 0 Td
(sub-type)Tj
3.6567 0 Td
(and)Tj
1.7291 0 Td
(age.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 379.1055 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(3.)Tj
1.0441 0 Td
(Results)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 362.0976 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Two)Tj
2.0182 0 Td
(hundred)Tj
3.6794 0 Td
(and)Tj
1.7291 0 Td
(forty-eight)Tj
4.473 0 Td
(subjects)Tj
3.3789 0 Td
(were)Tj
2.1203 0 Td
(recruited)Tj
3.8551 0 Td
(of)Tj
1.0148 0 Td
(whom)Tj
2.7552 0 Td
(44)Tj
1.1736 0 Td
(\(17.7%\))Tj
3.3108 0 Td
(were)Tj
2.1203 0 Td
(CRPS)Tj
2.5399 0 Td
(patients)Tj
-34.1686 -1.2982 Td
(\(27)Tj
1.508 0 Td
(men,)Tj
2.2393 0 Td
(61.4%\),)Tj
3.1975 0 Td
(3)Tj
0.6916 0 Td
(months)Tj
3.2825 0 Td
(to)Tj
1.0262 0 Td
(12-years)Tj
3.5659 0 Td
(post)Tj
1.9049 0 Td
(diagnosis)Tj
3.9571 0 Td
(\(mean)Tj
/F15 1 Tf
[()]TJ
/F8 1 Tf
(SD,)Tj
4.7906 0 Td
(3.18)Tj
/F15 1 Tf
[()]TJ
/F8 1 Tf
(3.16)Tj
4.0988 0 Td
(years;)Tj
2.4888 0 Td
(median,)Tj
-32.7512 -1.3039 Td
(2.01)Tj
1.8708 0 Td
(years\).)Tj
2.829 0 Td
(Specifically,)Tj
4.9152 0 Td
(CRPS)Tj
2.5398 0 Td
(type-I)Tj
2.6022 0 Td
(was)Tj
1.7008 0 Td
(diagnosed)Tj
4.2803 0 Td
(in)Tj
1.0375 0 Td
(35)Tj
1.1678 0 Td
(\(79.5%\))Tj
3.3109 0 Td
(patients)Tj
3.3675 0 Td
(while)Tj
2.3698 0 Td
(9)Tj
0.6973 0 Td
(\(20.5%\))Tj
-32.6889 -1.2983 Td
(were)Tj
2.1203 0 Td
(diagnosed)Tj
4.2802 0 Td
(with)Tj
2.0013 0 Td
(CRPS)Tj
2.5398 0 Td
(type-II.)Tj
3.1691 0 Td
(Two)Tj
2.0183 0 Td
(hundred)Tj
3.6793 0 Td
(and)Tj
1.7292 0 Td
(four)Tj
1.9105 0 Td
(individuals)Tj
4.6488 0 Td
(\(82.3%51.5%\))Tj
5.7203 0 Td
(served)Tj
2.7836 0 Td
(as)Tj
-36.6007 -1.2983 Td
(the)Tj
1.4683 0 Td
(healthy)Tj
3.1351 0 Td
(control)Tj
3.1181 0 Td
(group)Tj
2.6078 0 Td
(\(105)Tj
1.9899 0 Td
(men,)Tj
2.2337 0 Td
(51.5%\).)Tj
3.1975 0 Td
(Sex)Tj
1.5817 0 Td
(distribution)Tj
4.9719 0 Td
(differences)Tj
4.5638 0 Td
(between)Tj
3.5263 0 Td
(groups)Tj
2.9707 0 Td
(were)Tj
-35.3648 -1.3039 Td
(not)Tj
1.5703 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(statistically)Tj
4.6091 0 Td
(significant)Tj
4.388 0 Td
(\()Tj
/F6 1 Tf
(!)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 362.1543 301.5496 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 367.8803 297.0708 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(1\))Tj
1.3776 0 Td
(=)Tj
0.7993 0 Td
(1.42;)Tj
/F13 1 Tf
2.0977 0 Td
[()]TJ
/F8 1 Tf
0.6973 0 Td
(=)Tj
0.7994 0 Td
(0.233\).)Tj
2.9139 0 Td
(Mean)Tj
2.5172 0 Td
(age)Tj
1.542 0 Td
(was)Tj
1.7008 0 Td
(also)Tj
1.7688 0 Td
(not)Tj
1.5704 0 Td
(found)Tj
-34.571 -1.2982 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(statistically)Tj
4.6091 0 Td
(significant)Tj
4.388 0 Td
(between)Tj
3.5263 0 Td
(groups)Tj
2.9706 0 Td
(t\(45.162\))Tj
3.804 0 Td
(=)Tj
0.7994 0 Td
(-1.54;)Tj
/F13 1 Tf
2.4434 0 Td
[()]TJ
/F8 1 Tf
0.6974 0 Td
(=)Tj
0.7993 0 Td
(0.130;)Tj
2.5739 0 Td
(29.9)Tj
/F15 1 Tf
[()]TJ
/F8 1 Tf
(11.0)Tj
/F13 1 Tf
4.0932 0 Td
[()2()]TJ
/F8 1 Tf
(.)Tj
1.2075 0 Td
(27.4)Tj
/F15 1 Tf
[()]TJ
/F8 1 Tf
(3.7)Tj
-34.0891 -1.2983 Td
(years)Tj
2.262 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(CRPS)Tj
2.5399 0 Td
(\(range:)Tj
3.0273 0 Td
(1961)Tj
2.6419 0 Td
(years\))Tj
2.6022 0 Td
(and)Tj
1.729 0 Td
(control)Tj
3.1238 0 Td
(groups)Tj
2.9707 0 Td
(\(range:)Tj
3.0274 0 Td
(2340)Tj
2.6418 0 Td
(years\),)Tj
2.829 0 Td
(respectively.)Tj
0.83 0.64 0.02 0 k
-31.9008 -1.3039 Td
(Table)Tj
2.4378 0 Td
(1)Tj
0 g
0.6973 0 Td
(summarizes)Tj
5.0173 0 Td
(the)Tj
1.474 0 Td
(site)Tj
1.5647 0 Td
(and)Tj
1.7348 0 Td
(etiology)Tj
3.3845 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.474 0 Td
(patients)Tj
3.3676 0 Td
(with)Tj
1.9956 0 Td
(CRPS.)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 229.9839 m
576 229.9839 l
576 229.4838 l
36 229.4838 l
f*
100.9074 229.4838 m
100.9074 216.9839 l
100.4074 216.9839 l
100.4074 229.4838 l
f*
100.4074 216.9839 m
36 216.9839 l
36 217.4839 l
100.4074 217.4839 l
f*
169.7428 229.4838 m
169.7428 216.9839 l
169.2428 216.9839 l
169.2428 229.4838 l
f*
169.2428 216.9839 m
100.9074 216.9839 l
100.9074 217.4839 l
169.2428 217.4839 l
f*
534.0243 229.4838 m
534.0243 216.9839 l
533.5243 216.9839 l
533.5243 229.4838 l
f*
533.5243 216.9839 m
169.7428 216.9839 l
169.7428 217.4839 l
533.5243 217.4839 l
f*
575.9997 216.9839 m
534.0243 216.9839 l
534.0243 217.4839 l
575.9997 217.4839 l
f*
100.9074 216.9839 m
100.9074 191.984 l
100.4074 191.984 l
100.4074 216.9839 l
f*
100.4074 191.984 m
36 191.984 l
36 192.4841 l
100.4074 192.4841 l
f*
169.7428 216.9839 m
169.7428 204.484 l
169.2428 204.484 l
169.2428 216.9839 l
f*
169.2428 204.484 m
100.9074 204.484 l
100.9074 204.984 l
169.2428 204.984 l
f*
222.8513 216.9839 m
222.8513 191.984 l
222.3513 191.984 l
222.3513 216.9839 l
f*
222.3513 191.984 m
169.7428 191.984 l
169.7428 192.4841 l
222.3513 192.4841 l
f*
273.3015 216.9839 m
273.3015 191.984 l
272.8015 191.984 l
272.8015 216.9839 l
f*
272.8015 191.984 m
222.8513 191.984 l
222.8513 192.4841 l
272.8015 192.4841 l
f*
341.2919 216.9839 m
341.2919 191.984 l
340.7919 191.984 l
340.7919 216.9839 l
f*
340.7919 191.984 m
273.3015 191.984 l
273.3015 192.4841 l
340.7919 192.4841 l
f*
400.9632 216.9839 m
400.9632 191.984 l
400.4631 191.984 l
400.4631 216.9839 l
f*
400.4631 191.984 m
341.2919 191.984 l
341.2919 192.4841 l
400.4631 192.4841 l
f*
466.6277 216.9839 m
466.6277 191.984 l
466.1277 191.984 l
466.1277 216.9839 l
f*
466.1277 191.984 m
400.9632 191.984 l
400.9632 192.4841 l
466.1277 192.4841 l
f*
534.0243 216.9839 m
534.0243 191.984 l
533.5243 191.984 l
533.5243 216.9839 l
f*
533.5243 191.984 m
466.6277 191.984 l
466.6277 192.4841 l
533.5243 192.4841 l
f*
575.9997 191.984 m
534.0243 191.984 l
534.0243 192.4841 l
575.9997 192.4841 l
f*
135.7404 204.484 m
135.7404 191.984 l
135.2404 191.984 l
135.2404 204.484 l
f*
135.2404 191.984 m
100.9074 191.984 l
100.9074 192.4841 l
135.2404 192.4841 l
f*
169.7428 204.484 m
169.7428 191.984 l
169.2428 191.984 l
169.2428 204.484 l
f*
169.2428 191.984 m
135.7404 191.984 l
135.7404 192.4841 l
169.2428 192.4841 l
f*
100.9074 191.984 m
100.9074 179.4841 l
100.4074 179.4841 l
100.4074 191.984 l
f*
100.4074 179.4841 m
36 179.4841 l
36 179.9841 l
100.4074 179.9841 l
f*
135.7404 191.984 m
135.7404 179.4841 l
135.2404 179.4841 l
135.2404 191.984 l
f*
135.2404 179.4841 m
100.9074 179.4841 l
100.9074 179.9841 l
135.2404 179.9841 l
f*
169.7428 191.984 m
169.7428 179.4841 l
169.2428 179.4841 l
169.2428 191.984 l
f*
169.2428 179.4841 m
135.7404 179.4841 l
135.7404 179.9841 l
169.2428 179.9841 l
f*
222.8513 191.984 m
222.8513 179.4841 l
222.3513 179.4841 l
222.3513 191.984 l
f*
222.3513 179.4841 m
169.7428 179.4841 l
169.7428 179.9841 l
222.3513 179.9841 l
f*
273.3015 191.984 m
273.3015 179.4841 l
272.8015 179.4841 l
272.8015 191.984 l
f*
272.8015 179.4841 m
222.8513 179.4841 l
222.8513 179.9841 l
272.8015 179.9841 l
f*
341.2919 191.984 m
341.2919 179.4841 l
340.7919 179.4841 l
340.7919 191.984 l
f*
340.7919 179.4841 m
273.3015 179.4841 l
273.3015 179.9841 l
340.7919 179.9841 l
f*
400.9632 191.984 m
400.9632 179.4841 l
400.4631 179.4841 l
400.4631 191.984 l
f*
400.4631 179.4841 m
341.2919 179.4841 l
341.2919 179.9841 l
400.4631 179.9841 l
f*
466.6277 191.984 m
466.6277 179.4841 l
466.1277 179.4841 l
466.1277 191.984 l
f*
466.1277 179.4841 m
400.9632 179.4841 l
400.9632 179.9841 l
466.1277 179.9841 l
f*
534.0243 191.984 m
534.0243 179.4841 l
533.5243 179.4841 l
533.5243 191.984 l
f*
533.5243 179.4841 m
466.6277 179.4841 l
466.6277 179.9841 l
533.5243 179.9841 l
f*
575.9997 179.4841 m
534.0243 179.4841 l
534.0243 179.9841 l
575.9997 179.9841 l
f*
100.9074 179.4841 m
100.9074 166.9842 l
100.4074 166.9842 l
100.4074 179.4841 l
f*
100.4074 166.9842 m
36 166.9842 l
36 167.4842 l
100.4074 167.4842 l
f*
135.7404 179.4841 m
135.7404 166.9842 l
135.2404 166.9842 l
135.2404 179.4841 l
f*
135.2404 166.9842 m
100.9074 166.9842 l
100.9074 167.4842 l
135.2404 167.4842 l
f*
169.7428 179.4841 m
169.7428 166.9842 l
169.2428 166.9842 l
169.2428 179.4841 l
f*
169.2428 166.9842 m
135.7404 166.9842 l
135.7404 167.4842 l
169.2428 167.4842 l
f*
222.8513 179.4841 m
222.8513 166.9842 l
222.3513 166.9842 l
222.3513 179.4841 l
f*
222.3513 166.9842 m
169.7428 166.9842 l
169.7428 167.4842 l
222.3513 167.4842 l
f*
273.3015 179.4841 m
273.3015 166.9842 l
272.8015 166.9842 l
272.8015 179.4841 l
f*
272.8015 166.9842 m
222.8513 166.9842 l
222.8513 167.4842 l
272.8015 167.4842 l
f*
341.2919 179.4841 m
341.2919 166.9842 l
340.7919 166.9842 l
340.7919 179.4841 l
f*
340.7919 166.9842 m
273.3015 166.9842 l
273.3015 167.4842 l
340.7919 167.4842 l
f*
400.9632 179.4841 m
400.9632 166.9842 l
400.4631 166.9842 l
400.4631 179.4841 l
f*
400.4631 166.9842 m
341.2919 166.9842 l
341.2919 167.4842 l
400.4631 167.4842 l
f*
466.6277 179.4841 m
466.6277 166.9842 l
466.1277 166.9842 l
466.1277 179.4841 l
f*
466.1277 166.9842 m
400.9632 166.9842 l
400.9632 167.4842 l
466.1277 167.4842 l
f*
534.0243 179.4841 m
534.0243 166.9842 l
533.5243 166.9842 l
533.5243 179.4841 l
f*
533.5243 166.9842 m
466.6277 166.9842 l
466.6277 167.4842 l
533.5243 167.4842 l
f*
575.9997 166.9842 m
534.0243 166.9842 l
534.0243 167.4842 l
575.9997 167.4842 l
f*
100.9074 166.9842 m
100.9074 154.4842 l
100.4074 154.4842 l
100.4074 166.9842 l
f*
100.4074 154.4842 m
36 154.4842 l
36 154.9843 l
100.4074 154.9843 l
f*
135.7404 166.9842 m
135.7404 154.4842 l
135.2404 154.4842 l
135.2404 166.9842 l
f*
135.2404 154.4842 m
100.9074 154.4842 l
100.9074 154.9843 l
135.2404 154.9843 l
f*
169.7428 166.9842 m
169.7428 154.4842 l
169.2428 154.4842 l
169.2428 166.9842 l
f*
169.2428 154.4842 m
135.7404 154.4842 l
135.7404 154.9843 l
169.2428 154.9843 l
f*
222.8513 166.9842 m
222.8513 154.4842 l
222.3513 154.4842 l
222.3513 166.9842 l
f*
222.3513 154.4842 m
169.7428 154.4842 l
169.7428 154.9843 l
222.3513 154.9843 l
f*
273.3015 166.9842 m
273.3015 154.4842 l
272.8015 154.4842 l
272.8015 166.9842 l
f*
272.8015 154.4842 m
222.8513 154.4842 l
222.8513 154.9843 l
272.8015 154.9843 l
f*
341.2919 166.9842 m
341.2919 154.4842 l
340.7919 154.4842 l
340.7919 166.9842 l
f*
340.7919 154.4842 m
273.3015 154.4842 l
273.3015 154.9843 l
340.7919 154.9843 l
f*
400.9632 166.9842 m
400.9632 154.4842 l
400.4631 154.4842 l
400.4631 166.9842 l
f*
400.4631 154.4842 m
341.2919 154.4842 l
341.2919 154.9843 l
400.4631 154.9843 l
f*
466.6277 166.9842 m
466.6277 154.4842 l
466.1277 154.4842 l
466.1277 166.9842 l
f*
466.1277 154.4842 m
400.9632 154.4842 l
400.9632 154.9843 l
466.1277 154.9843 l
f*
534.0243 166.9842 m
534.0243 154.4842 l
533.5243 154.4842 l
533.5243 166.9842 l
f*
533.5243 154.4842 m
466.6277 154.4842 l
466.6277 154.9843 l
533.5243 154.9843 l
f*
575.9997 154.4842 m
534.0243 154.4842 l
534.0243 154.9843 l
575.9997 154.9843 l
f*
100.9074 154.4842 m
100.9074 141.9843 l
100.4074 141.9843 l
100.4074 154.4842 l
f*
100.4074 141.9843 m
36 141.9843 l
36 142.4843 l
100.4074 142.4843 l
f*
135.7404 154.4842 m
135.7404 141.9843 l
135.2404 141.9843 l
135.2404 154.4842 l
f*
135.2404 141.9843 m
100.9074 141.9843 l
100.9074 142.4843 l
135.2404 142.4843 l
f*
169.7428 154.4842 m
169.7428 141.9843 l
169.2428 141.9843 l
169.2428 154.4842 l
f*
169.2428 141.9843 m
135.7404 141.9843 l
135.7404 142.4843 l
169.2428 142.4843 l
f*
222.8513 154.4842 m
222.8513 141.9843 l
222.3513 141.9843 l
222.3513 154.4842 l
f*
222.3513 141.9843 m
169.7428 141.9843 l
169.7428 142.4843 l
222.3513 142.4843 l
f*
273.3015 154.4842 m
273.3015 141.9843 l
272.8015 141.9843 l
272.8015 154.4842 l
f*
272.8015 141.9843 m
222.8513 141.9843 l
222.8513 142.4843 l
272.8015 142.4843 l
f*
341.2919 154.4842 m
341.2919 141.9843 l
340.7919 141.9843 l
340.7919 154.4842 l
f*
340.7919 141.9843 m
273.3015 141.9843 l
273.3015 142.4843 l
340.7919 142.4843 l
f*
400.9632 154.4842 m
400.9632 141.9843 l
400.4631 141.9843 l
400.4631 154.4842 l
f*
400.4631 141.9843 m
341.2919 141.9843 l
341.2919 142.4843 l
400.4631 142.4843 l
f*
466.6277 154.4842 m
466.6277 141.9843 l
466.1277 141.9843 l
466.1277 154.4842 l
f*
466.1277 141.9843 m
400.9632 141.9843 l
400.9632 142.4843 l
466.1277 142.4843 l
f*
534.0243 154.4842 m
534.0243 141.9843 l
533.5243 141.9843 l
533.5243 154.4842 l
f*
533.5243 141.9843 m
466.6277 141.9843 l
466.6277 142.4843 l
533.5243 142.4843 l
f*
575.9997 141.9843 m
534.0243 141.9843 l
534.0243 142.4843 l
575.9997 142.4843 l
f*
100.9074 141.9843 m
100.9074 129.4843 l
100.4074 129.4843 l
100.4074 141.9843 l
f*
100.4074 129.4843 m
36 129.4843 l
36 129.9844 l
100.4074 129.9844 l
f*
135.7404 141.9843 m
135.7404 129.4843 l
135.2404 129.4843 l
135.2404 141.9843 l
f*
135.2404 129.4843 m
100.9074 129.4843 l
100.9074 129.9844 l
135.2404 129.9844 l
f*
169.7428 141.9843 m
169.7428 129.4843 l
169.2428 129.4843 l
169.2428 141.9843 l
f*
169.2428 129.4843 m
135.7404 129.4843 l
135.7404 129.9844 l
169.2428 129.9844 l
f*
222.8513 141.9843 m
222.8513 129.4843 l
222.3513 129.4843 l
222.3513 141.9843 l
f*
222.3513 129.4843 m
169.7428 129.4843 l
169.7428 129.9844 l
222.3513 129.9844 l
f*
273.3015 141.9843 m
273.3015 129.4843 l
272.8015 129.4843 l
272.8015 141.9843 l
f*
272.8015 129.4843 m
222.8513 129.4843 l
222.8513 129.9844 l
272.8015 129.9844 l
f*
341.2919 141.9843 m
341.2919 129.4843 l
340.7919 129.4843 l
340.7919 141.9843 l
f*
340.7919 129.4843 m
273.3015 129.4843 l
273.3015 129.9844 l
340.7919 129.9844 l
f*
400.9632 141.9843 m
400.9632 129.4843 l
400.4631 129.4843 l
400.4631 141.9843 l
f*
400.4631 129.4843 m
341.2919 129.4843 l
341.2919 129.9844 l
400.4631 129.9844 l
f*
466.6277 141.9843 m
466.6277 129.4843 l
466.1277 129.4843 l
466.1277 141.9843 l
f*
466.1277 129.4843 m
400.9632 129.4843 l
400.9632 129.9844 l
466.1277 129.9844 l
f*
534.0243 141.9843 m
534.0243 129.4843 l
533.5243 129.4843 l
533.5243 141.9843 l
f*
533.5243 129.4843 m
466.6277 129.4843 l
466.6277 129.9844 l
533.5243 129.9844 l
f*
575.9997 129.4843 m
534.0243 129.4843 l
534.0243 129.9844 l
575.9997 129.9844 l
f*
100.9074 129.4843 m
100.9074 116.9844 l
100.4074 116.9844 l
100.4074 129.4843 l
f*
100.4074 116.9844 m
36 116.9844 l
36 117.4844 l
100.4074 117.4844 l
f*
135.7404 129.4843 m
135.7404 116.9844 l
135.2404 116.9844 l
135.2404 129.4843 l
f*
135.2404 116.9844 m
100.9074 116.9844 l
100.9074 117.4844 l
135.2404 117.4844 l
f*
169.7428 129.4843 m
169.7428 116.9844 l
169.2428 116.9844 l
169.2428 129.4843 l
f*
169.2428 116.9844 m
135.7404 116.9844 l
135.7404 117.4844 l
169.2428 117.4844 l
f*
222.8513 129.4843 m
222.8513 116.9844 l
222.3513 116.9844 l
222.3513 129.4843 l
f*
222.3513 116.9844 m
169.7428 116.9844 l
169.7428 117.4844 l
222.3513 117.4844 l
f*
273.3015 129.4843 m
273.3015 116.9844 l
272.8015 116.9844 l
272.8015 129.4843 l
f*
272.8015 116.9844 m
222.8513 116.9844 l
222.8513 117.4844 l
272.8015 117.4844 l
f*
341.2919 129.4843 m
341.2919 116.9844 l
340.7919 116.9844 l
340.7919 129.4843 l
f*
340.7919 116.9844 m
273.3015 116.9844 l
273.3015 117.4844 l
340.7919 117.4844 l
f*
400.9632 129.4843 m
400.9632 116.9844 l
400.4631 116.9844 l
400.4631 129.4843 l
f*
400.4631 116.9844 m
341.2919 116.9844 l
341.2919 117.4844 l
400.4631 117.4844 l
f*
466.6277 129.4843 m
466.6277 116.9844 l
466.1277 116.9844 l
466.1277 129.4843 l
f*
466.1277 116.9844 m
400.9632 116.9844 l
400.9632 117.4844 l
466.1277 117.4844 l
f*
534.0243 129.4843 m
534.0243 116.9844 l
533.5243 116.9844 l
533.5243 129.4843 l
f*
533.5243 116.9844 m
466.6277 116.9844 l
466.6277 117.4844 l
533.5243 117.4844 l
f*
575.9997 116.9844 m
534.0243 116.9844 l
534.0243 117.4844 l
575.9997 117.4844 l
f*
100.9074 116.9844 m
100.9074 104.4845 l
100.4074 104.4845 l
100.4074 116.9844 l
f*
100.4074 104.4845 m
36 104.4845 l
36 104.9845 l
100.4074 104.9845 l
f*
135.7404 116.9844 m
135.7404 104.4845 l
135.2404 104.4845 l
135.2404 116.9844 l
f*
135.2404 104.4845 m
100.9074 104.4845 l
100.9074 104.9845 l
135.2404 104.9845 l
f*
169.7428 116.9844 m
169.7428 104.4845 l
169.2428 104.4845 l
169.2428 116.9844 l
f*
169.2428 104.4845 m
135.7404 104.4845 l
135.7404 104.9845 l
169.2428 104.9845 l
f*
222.8513 116.9844 m
222.8513 104.4845 l
222.3513 104.4845 l
222.3513 116.9844 l
f*
222.3513 104.4845 m
169.7428 104.4845 l
169.7428 104.9845 l
222.3513 104.9845 l
f*
273.3015 116.9844 m
273.3015 104.4845 l
272.8015 104.4845 l
272.8015 116.9844 l
f*
272.8015 104.4845 m
222.8513 104.4845 l
222.8513 104.9845 l
272.8015 104.9845 l
f*
341.2919 116.9844 m
341.2919 104.4845 l
340.7919 104.4845 l
340.7919 116.9844 l
f*
340.7919 104.4845 m
273.3015 104.4845 l
273.3015 104.9845 l
340.7919 104.9845 l
f*
400.9632 116.9844 m
400.9632 104.4845 l
400.4631 104.4845 l
400.4631 116.9844 l
f*
400.4631 104.4845 m
341.2919 104.4845 l
341.2919 104.9845 l
400.4631 104.9845 l
f*
466.6277 116.9844 m
466.6277 104.4845 l
466.1277 104.4845 l
466.1277 116.9844 l
f*
466.1277 104.4845 m
400.9632 104.4845 l
400.9632 104.9845 l
466.1277 104.9845 l
f*
534.0243 116.9844 m
534.0243 104.4845 l
533.5243 104.4845 l
533.5243 116.9844 l
f*
533.5243 104.4845 m
466.6277 104.4845 l
466.6277 104.9845 l
533.5243 104.9845 l
f*
575.9997 104.4845 m
534.0243 104.4845 l
534.0243 104.9845 l
575.9997 104.9845 l
f*
0.83 0.64 0.02 0 k
36 91.389 m
186.7465 91.389 l
h
f*
0 g
7.9999 0 0 7.9999 36 234.822 cm
BT
/F12 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(1.)Tj
1.1763 0 Td
(CRPS)Tj
2.6292 0 Td
(site)Tj
1.6583 0 Td
(and)Tj
1.7787 0 Td
(etiology)Tj
3.5292 0 Td
(\(N)Tj
1.2969 0 Td
(=)Tj
0.7866 0 Td
(44\).)Tj
0 Tc
-7.0442 -1.8567 Td
(Location)Tj
29.3459 0 Td
(Etiology)Tj
24.7963 0 Td
(Total)Tj
-54.1422 -1.559 Td
(Body-side)Tj
8.6032 0 Td
(Fracture)Tj
6.6402 0 Td
(Surgery)Tj
6.3072 0 Td
(Crush)Tj
2.7921 0 Td
(Injury)Tj
5.7048 0 Td
(Contusion)Tj
7.4623 0 Td
(Tendon)Tj
3.5008 0 Td
(tear)Tj
4.7055 0 Td
(Unidentif)Tj
4.089 0 Td
(ied)Tj
4.3371 0 Td
(n)Tj
-54.1422 -1.5662 Td
(RT)Tj
4.3583 0 Td
(LT)Tj
-12.7205 -1.559 Td
(Hand)Tj
2.5866 0 Td
(\(palm\))Tj
/F8 1 Tf
5.9032 0 Td
(2)Tj
4.3512 0 Td
(2)Tj
4.252 0 Td
(1)Tj
6.6402 0 Td
(1)Tj
6.3071 0 Td
(2)Tj
8.497 0 Td
(0)Tj
7.4551 0 Td
(0)Tj
8.2135 0 Td
(0)Tj
8.426 0 Td
(4)Tj
/F12 1 Tf
-62.6319 -1.5662 Td
(Wrist)Tj
/F8 1 Tf
8.4898 0 Td
(1)Tj
4.3512 0 Td
(3)Tj
4.252 0 Td
(2)Tj
6.6402 0 Td
(1)Tj
6.3071 0 Td
(0)Tj
8.497 0 Td
(0)Tj
7.4551 0 Td
(1)Tj
8.2135 0 Td
(0)Tj
8.426 0 Td
(4)Tj
/F12 1 Tf
-62.6319 -1.5591 Td
(Shoulder)Tj
/F8 1 Tf
8.4898 0 Td
(3)Tj
4.3512 0 Td
(0)Tj
4.252 0 Td
(0)Tj
6.6402 0 Td
(2)Tj
6.3071 0 Td
(0)Tj
8.497 0 Td
(1)Tj
7.4551 0 Td
(0)Tj
8.2135 0 Td
(0)Tj
8.426 0 Td
(3)Tj
/F12 1 Tf
-62.6319 -1.5661 Td
(Knee)Tj
/F8 1 Tf
8.4898 0 Td
(3)Tj
4.3512 0 Td
(1)Tj
4.252 0 Td
(1)Tj
6.6402 0 Td
(2)Tj
6.3071 0 Td
(1)Tj
8.497 0 Td
(0)Tj
7.4551 0 Td
(0)Tj
8.2135 0 Td
(0)Tj
8.426 0 Td
(4)Tj
/F12 1 Tf
-62.6319 -1.5591 Td
(Ankle)Tj
/F8 1 Tf
8.4898 0 Td
(4)Tj
4.3512 0 Td
(1)Tj
4.252 0 Td
(2)Tj
6.6402 0 Td
(1)Tj
6.3071 0 Td
(2)Tj
8.497 0 Td
(0)Tj
7.4551 0 Td
(0)Tj
8.2135 0 Td
(0)Tj
8.426 0 Td
(5)Tj
/F12 1 Tf
-62.6319 -1.5661 Td
(Foot)Tj
/F8 1 Tf
8.4898 0 Td
(13)Tj
4.3512 0 Td
(11)Tj
4.252 0 Td
(8)Tj
6.6402 0 Td
(7)Tj
6.3071 0 Td
(6)Tj
8.497 0 Td
(1)Tj
7.4551 0 Td
(1)Tj
8.2135 0 Td
(1)Tj
8.426 0 Td
(24)Tj
/F12 1 Tf
-62.6319 -1.5591 Td
(Total)Tj
/F8 1 Tf
8.4898 0 Td
(26)Tj
4.3512 0 Td
(18)Tj
4.252 0 Td
(14)Tj
6.6402 0 Td
(14)Tj
6.3071 0 Td
(11)Tj
8.497 0 Td
(2)Tj
7.4551 0 Td
(2)Tj
8.2135 0 Td
(1)Tj
8.426 0 Td
(44)Tj
0.83 0.64 0.02 0 k
/F10 1 Tf
-0.025 Tc
-62.6319 -1.878 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pone)Tj
4.4079 0 Td
(.0201354.t001)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 472.2519 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(SMD)Tj
2.4165 0 Td
(is)Tj
0.9213 0 Td
(associated)Tj
4.9181 0 Td
(with)Tj
1.963 0 Td
(CRPS)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02013)Tj
4.089 0 Td
(54)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(9,)Tj
1.0418 0 Td
(2018)Tj
34.5758 0 Td
(5)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
176 0 obj
<>stream
endstream
endobj
177 0 obj
<>stream
endstream
endobj
178 0 obj
<>stream
endstream
endobj
179 0 obj
<>stream
endstream
endobj
180 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
181 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 182 0 R/Contents 183 0 R/TrimBox[0 0 612 792]>>
endobj
182 0 obj
[184 0 R 185 0 R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R]
endobj
184 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.t002)>>
endobj
185 0 obj
<>/Border[0 0 0]/Dest(Rpone.0201354.t003)>>
endobj
186 0 obj
<>/Border[0 0 0]/Dest(Lpone.0201354.t002)>>
endobj
187 0 obj
<>/Border[0 0 0]/A 191 0 R>>
endobj
191 0 obj
<>
endobj
188 0 obj
<>/Border[0 0 0]/Dest(Lpone.0201354.t003)>>
endobj
189 0 obj
<>/Border[0 0 0]/A 192 0 R>>
endobj
192 0 obj
<>
endobj
190 0 obj
<>/Border[0 0 0]/A 193 0 R>>
endobj
193 0 obj
<>
endobj
183 0 obj
[194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R]
endobj
194 0 obj
<>stream
q
0.83 0.64 0.02 0 k
489.7701 484.611 m
518.9669 484.611 l
h
f*
400.0252 224.3339 m
429.2787 224.3339 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 580.7055 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(3.1)Tj
1.4598 0 Td
(SMD)Tj
2.3528 0 Td
(distribution)Tj
5.2488 0 Td
(in)Tj
1.0678 0 Td
(CRPS)Tj
2.6409 0 Td
(and)Tj
1.7906 0 Td
(in)Tj
1.0677 0 Td
(healthy)Tj
3.2977 0 Td
(controls)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 563.6976 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Thirty-four)Tj
4.7961 0 Td
(percent)Tj
3.2258 0 Td
(\(N)Tj
1.2926 0 Td
(=)Tj
0.7994 0 Td
(15\))Tj
1.5137 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(individuals)Tj
4.6488 0 Td
(with)Tj
2.0013 0 Td
(CRPS)Tj
2.5341 0 Td
(and)Tj
1.7348 0 Td
(12.8%)Tj
2.6249 0 Td
(\(N)Tj
1.2982 0 Td
(=)Tj
0.7994 0 Td
(26\))Tj
1.5137 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(healthy)Tj
-33.749 -1.2982 Td
(controls)Tj
3.4809 0 Td
(were)Tj
2.1203 0 Td
(identified)Tj
4.0592 0 Td
(with)Tj
2.0012 0 Td
(SMD.)Tj
2.5455 0 Td
(This)Tj
1.9899 0 Td
(difference)Tj
4.2066 0 Td
(was)Tj
1.6951 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(statistically)Tj
4.6091 0 Td
(significant)Tj
-31.504 -1.3039 Td
(\()Tj
/F6 1 Tf
(!)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 208.4598 542.1543 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 214.2425 537.6755 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(1\))Tj
1.3719 0 Td
(=)Tj
0.7994 0 Td
(11.95;)Tj
/F13 1 Tf
2.5738 0 Td
[()]TJ
/F14 1 Tf
0 Tc
(<)Tj
/F8 1 Tf
-0.004 Tc
(0.001\).)Tj
4.1613 0 Td
(SMD)Tj
2.3243 0 Td
(sub-types)Tj
4.0252 0 Td
(distribution)Tj
4.9663 0 Td
(was)Tj
1.7008 0 Td
(also)Tj
1.7631 0 Td
(found)Tj
2.6192 0 Td
(statistically)Tj
4.6091 0 Td
(different)Tj
-32.3373 -1.2982 Td
(between)Tj
3.5205 0 Td
(groups:)Tj
3.1861 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.4627 0 Td
(CRPS)Tj
2.5341 0 Td
(group)Tj
2.6022 0 Td
(25%)Tj
1.9219 0 Td
(\(N)Tj
1.2869 0 Td
(=)Tj
0.7937 0 Td
(11\))Tj
1.5024 0 Td
(and)Tj
1.7234 0 Td
(9.1%)Tj
2.1487 0 Td
(\(N)Tj
1.2926 0 Td
(=)Tj
0.788 0 Td
(4\))Tj
1.0318 0 Td
(met)Tj
1.7575 0 Td
(the)Tj
1.4626 0 Td
(criteria)Tj
3.0671 0 Td
(for)Tj
1.3776 0 Td
(sensory)Tj
-34.5653 -1.2983 Td
(over-responsiveness)Tj
8.2543 0 Td
(and)Tj
1.7291 0 Td
(sensory)Tj
3.2485 0 Td
(under-responsiveness,)Tj
9.1218 0 Td
(respectively,)Tj
5.1137 0 Td
(versus)Tj
2.7156 0 Td
(the)Tj
1.474 0 Td
(control)Tj
3.1181 0 Td
(group)Tj
-34.7751 -1.3039 Td
(in)Tj
1.0318 0 Td
(which)Tj
2.6531 0 Td
(11.3%)Tj
2.6305 0 Td
(\(N)Tj
1.2926 0 Td
(=)Tj
0.7994 0 Td
(23\))Tj
1.5137 0 Td
(and)Tj
1.7291 0 Td
(1.5%)Tj
2.1543 0 Td
(\(N)Tj
1.2983 0 Td
(=)Tj
0.7993 0 Td
(3\))Tj
1.0375 0 Td
(met)Tj
1.7575 0 Td
(the)Tj
1.474 0 Td
(criteria)Tj
3.0727 0 Td
(for)Tj
1.389 0 Td
(sensory)Tj
3.2428 0 Td
(over-responsivene)Tj
7.319 0 Td
(ss)Tj
-35.1946 -1.2983 Td
(and)Tj
1.729 0 Td
(sensory)Tj
3.2485 0 Td
(under-responsiveness,)Tj
9.1218 0 Td
(respectively)Tj
4.8869 0 Td
(\()Tj
/F6 1 Tf
(!)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 398.3244 490.1102 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 404.107 485.6881 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(1\))Tj
1.3719 0 Td
(=)Tj
0.7994 0 Td
(14.39,)Tj
/F13 1 Tf
2.5738 0 Td
[()]TJ
/F14 1 Tf
0 Tc
(<)Tj
/F8 1 Tf
-0.004 Tc
(0.001;)Tj
0.83 0.64 0.02 0 k
3.8211 0 Td
(Table)Tj
2.4434 0 Td
(2)Tj
0 g
(\).)Tj
1.2586 0 Td
(Of)Tj
1.2586 0 Td
(note,)Tj
2.2223 0 Td
(no)Tj
-36.1584 -1.2982 Td
(differences)Tj
4.5638 0 Td
(were)Tj
2.1203 0 Td
(found)Tj
2.6192 0 Td
(in)Tj
1.0375 0 Td
(both)Tj
2.0579 0 Td
(sensory)Tj
3.2485 0 Td
(over-responsiveness)Tj
8.2543 0 Td
(and)Tj
1.7348 0 Td
(sensory)Tj
3.2428 0 Td
(under-responsivenes)Tj
8.3225 0 Td
(s)Tj
-37.2016 -1.2983 Td
(scores)Tj
2.6646 0 Td
(within)Tj
2.8119 0 Td
(the)Tj
1.474 0 Td
(CRPS)Tj
2.5399 0 Td
(group)Tj
2.6078 0 Td
(between)Tj
3.5263 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
2.0012 0 Td
(CRPS)Tj
2.5341 0 Td
(type)Tj
1.9162 0 Td
(1)Tj
/F13 1 Tf
0.6974 0 Td
[()2()]TJ
/F8 1 Tf
(.)Tj
1.2075 0 Td
(patients)Tj
3.3676 0 Td
(with)Tj
1.9955 0 Td
(CRPS)Tj
2.5399 0 Td
(type)Tj
-35.2514 -1.3039 Td
(2)Tj
0.6917 0 Td
(\(for)Tj
1.7291 0 Td
(sensory)Tj
3.2485 0 Td
(over-responsiveness:)Tj
8.4812 0 Td
(2.17)Tj
/F15 1 Tf
[()]TJ
/F8 1 Tf
(0.42)Tj
4.0932 0 Td
(and)Tj
1.7291 0 Td
(2.15)Tj
/F15 1 Tf
[()]TJ
/F8 1 Tf
(0.49;)Tj
4.3199 0 Td
(for)Tj
1.3833 0 Td
(sensory)Tj
3.2485 0 Td
(under-responsive-)Tj
-28.9245 -1.2983 Td
(ness:)Tj
2.1373 0 Td
(1.98)Tj
/F15 1 Tf
[()]TJ
/F8 1 Tf
(0.47)Tj
4.0932 0 Td
(and)Tj
1.7292 0 Td
(1.96)Tj
/F15 1 Tf
[()]TJ
/F8 1 Tf
(0.16,)Tj
4.3199 0 Td
(respectively\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 405.5811 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(3.2)Tj
1.4598 0 Td
(Distribution)Tj
5.4567 0 Td
(of)Tj
1.063 0 Td
(SMD)Tj
2.3575 0 Td
(subtypes)Tj
3.8457 0 Td
(and)Tj
1.7906 0 Td
(their)Tj
2.2347 0 Td
(associations)Tj
5.2252 0 Td
(with)Tj
2.0788 0 Td
(CRPS)Tj
-25.512 -1.1669 Td
(Severity)Tj
3.5433 0 Td
(Score)Tj
2.4945 0 Td
(parameters)Tj
4.9323 0 Td
(in)Tj
1.0677 0 Td
(the)Tj
1.5402 0 Td
(CRPS)Tj
2.641 0 Td
(group)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 374.57 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(CRPS)Tj
2.5398 0 Td
(Severity)Tj
3.3845 0 Td
(Score)Tj
2.4265 0 Td
(parameters)Tj
4.6714 0 Td
(were)Tj
2.1203 0 Td
(compared)Tj
4.2463 0 Td
(between)Tj
3.5263 0 Td
(SMD)Tj
2.3244 0 Td
(subtypes)Tj
3.6737 0 Td
(\(i.e.)Tj
1.7007 0 Td
(sensory)Tj
3.2485 0 Td
(over-)Tj
-33.8624 -1.3039 Td
(responsiveness;)Tj
6.3722 0 Td
(sensory)Tj
3.2485 0 Td
(under-responsiveness;)Tj
9.1218 0 Td
(and)Tj
1.7291 0 Td
(Non-SMD\))Tj
4.8076 0 Td
(within)Tj
2.8119 0 Td
(the)Tj
1.474 0 Td
(CRPS)Tj
2.5398 0 Td
(group)Tj
2.6079 0 Td
(for)Tj
-34.7128 -1.2982 Td
(each)Tj
2.0295 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(CSS)Tj
1.8311 0 Td
(variables:)Tj
3.9458 0 Td
(\(8)Tj
1.0375 0 Td
(self-report)Tj
4.3767 0 Td
(symptoms)Tj
4.3596 0 Td
(and)Tj
1.7292 0 Td
(9)Tj
0.6973 0 Td
(signs)Tj
2.2223 0 Td
(observed)Tj
3.7928 0 Td
(on)Tj
1.2755 0 Td
(examination)Tj
5.2328 0 Td
(by)Tj
1.1848 0 Td
(a)Tj
-36.1981 -1.2983 Td
(clinician,)Tj
3.8721 0 Td
(a)Tj
0.6519 0 Td
(total)Tj
2.0013 0 Td
(of)Tj
1.0148 0 Td
(17)Tj
1.1735 0 Td
(items\).)Tj
2.9537 0 Td
(No)Tj
1.4626 0 Td
(statistically)Tj
4.6092 0 Td
(significant)Tj
4.388 0 Td
(differences)Tj
4.5694 0 Td
(were)Tj
2.1203 0 Td
(found)Tj
2.6192 0 Td
(between)Tj
3.5319 0 Td
(SMD)Tj
-34.9679 -1.2983 Td
(subtypes)Tj
3.668 0 Td
(\(Kruskal-Wallis)Tj
6.5423 0 Td
(test)Tj
1.5987 0 Td
(p)Tj
/F14 1 Tf
0 Tc
(>)Tj
/F8 1 Tf
-0.004 Tc
(0.05\))Tj
3.5036 0 Td
(in)Tj
1.0375 0 Td
(each)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(CRPS)Tj
2.5398 0 Td
(Severity)Tj
3.3846 0 Td
(Score)Tj
2.4208 0 Td
(parameters)Tj
4.6771 0 Td
(tested.)Tj
-33.8851 -1.3039 Td
(CRPS)Tj
2.5398 0 Td
(Severity)Tj
3.3845 0 Td
(Score)Tj
2.4265 0 Td
(parameters)Tj
4.6714 0 Td
(were)Tj
2.1203 0 Td
(also)Tj
1.7688 0 Td
(not)Tj
1.5761 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(statistically)Tj
4.6091 0 Td
(significant)Tj
4.388 0 Td
(different)Tj
-32.2807 -1.2982 Td
(between)Tj
3.5262 0 Td
(males)Tj
2.5058 0 Td
(and)Tj
1.7292 0 Td
(females)Tj
/F13 1 Tf
3.2144 0 Td
[()]TJ
/F8 1 Tf
0.6973 0 Td
(=)Tj
0.7994 0 Td
(1.00)Tj
1.8709 0 Td
(\(Fisher's)Tj
3.617 0 Td
(exact)Tj
2.262 0 Td
(test\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 268.4409 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(3.3)Tj
1.4598 0 Td
(SMD)Tj
2.3528 0 Td
(subtypes)Tj
3.8457 0 Td
(as)Tj
1.0677 0 Td
(risk)Tj
1.8 0 Td
(factors)Tj
3.0756 0 Td
(for)Tj
1.4693 0 Td
(CRPS)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 251.433 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(SMD)Tj
2.3243 0 Td
(subtypes)Tj
3.6681 0 Td
(\(sensory)Tj
3.5886 0 Td
(over-responsiveness)Tj
8.2544 0 Td
([Yes/No])Tj
/F13 1 Tf
3.8891 0 Td
[()2()]TJ
/F8 1 Tf
(.)Tj
1.2076 0 Td
(Non-SMD,)Tj
4.6941 0 Td
(and)Tj
1.7292 0 Td
(sensory)Tj
3.2484 0 Td
(under-)Tj
-32.6038 -1.3039 Td
(responsiveness)Tj
6.1454 0 Td
([Yes/No])Tj
/F13 1 Tf
3.8891 0 Td
[()2()]TJ
/F8 1 Tf
(.)Tj
1.2133 0 Td
(Non-SMD])Tj
4.8075 0 Td
(and)Tj
1.7291 0 Td
(age)Tj
1.542 0 Td
(were)Tj
2.1203 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(significantly)Tj
5.091 0 Td
(related)Tj
2.9424 0 Td
(to)Tj
-34.2763 -1.2982 Td
(CRPS)Tj
2.5398 0 Td
(in)Tj
1.0318 0 Td
(both)Tj
2.0636 0 Td
(univariate)Tj
4.2463 0 Td
(and)Tj
1.7291 0 Td
(multivariate)Tj
5.0626 0 Td
(models.)Tj
0.83 0.64 0.02 0 k
3.3279 0 Td
(Table)Tj
2.4434 0 Td
(3)Tj
0 g
0.6974 0 Td
(shows)Tj
2.6588 0 Td
(the)Tj
1.4684 0 Td
(adjusted)Tj
3.5773 0 Td
(odds)Tj
2.1429 0 Td
(ratios,)Tj
2.6873 0 Td
(95%)Tj
-35.6766 -1.2983 Td
(confidence)Tj
4.5977 0 Td
(intervals)Tj
3.6283 0 Td
(and)Tj
1.7292 0 Td
(level)Tj
2.0125 0 Td
(of)Tj
1.0148 0 Td
(significance)Tj
4.938 0 Td
(when)Tj
2.4037 0 Td
(both)Tj
2.058 0 Td
(variables)Tj
3.719 0 Td
(were)Tj
2.126 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(model.)Tj
2.965 0 Td
(The)Tj
1.7858 0 Td
(odds)Tj
-35.4838 -1.3039 Td
(ratio)Tj
2.0976 0 Td
(for)Tj
1.3833 0 Td
(age)Tj
1.542 0 Td
(is)Tj
0.8504 0 Td
(presented)Tj
4.1159 0 Td
(in)Tj
1.0318 0 Td
(5-year)Tj
2.7326 0 Td
(increments)Tj
4.7054 0 Td
(for)Tj
1.3833 0 Td
(ease)Tj
1.8652 0 Td
(of)Tj
1.0148 0 Td
(interpretation.)Tj
6.0208 0 Td
(For)Tj
1.6214 0 Td
(a)Tj
0.6576 0 Td
(patient)Tj
3.0047 0 Td
(with)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
199.9998 703.8893 m
575.9997 703.8893 l
575.9997 703.3893 l
199.9998 703.3893 l
f*
320.8507 703.3893 m
320.8507 681.3893 l
320.3507 681.3893 l
320.3507 703.3893 l
f*
320.3507 681.3893 m
199.9998 681.3893 l
199.9998 681.8893 l
320.3507 681.8893 l
f*
431.1986 703.3893 m
431.1986 681.3893 l
430.6986 681.3893 l
430.6986 703.3893 l
f*
430.6986 681.3893 m
320.8507 681.3893 l
320.8507 681.8893 l
430.6986 681.8893 l
f*
530.581 703.3893 m
530.581 681.3893 l
530.081 681.3893 l
530.081 703.3893 l
f*
530.081 681.3893 m
431.1986 681.3893 l
431.1986 681.8893 l
530.081 681.8893 l
f*
575.9989 681.3893 m
530.581 681.3893 l
530.581 681.8893 l
575.9989 681.8893 l
f*
320.8507 681.3893 m
320.8507 668.8894 l
320.3507 668.8894 l
320.3507 681.3893 l
f*
320.3507 668.8894 m
199.9998 668.8894 l
199.9998 669.3894 l
320.3507 669.3894 l
f*
431.1986 681.3893 m
431.1986 668.8894 l
430.6986 668.8894 l
430.6986 681.3893 l
f*
430.6986 668.8894 m
320.8507 668.8894 l
320.8507 669.3894 l
430.6986 669.3894 l
f*
530.581 681.3893 m
530.581 668.8894 l
530.081 668.8894 l
530.081 681.3893 l
f*
530.081 668.8894 m
431.1986 668.8894 l
431.1986 669.3894 l
530.081 669.3894 l
f*
575.9989 668.8894 m
530.581 668.8894 l
530.581 669.3894 l
575.9989 669.3894 l
f*
320.8507 668.8894 m
320.8507 656.3894 l
320.3507 656.3894 l
320.3507 668.8894 l
f*
320.3507 656.3894 m
199.9998 656.3894 l
199.9998 656.8894 l
320.3507 656.8894 l
f*
431.1986 668.8894 m
431.1986 656.3894 l
430.6986 656.3894 l
430.6986 668.8894 l
f*
430.6986 656.3894 m
320.8507 656.3894 l
320.8507 656.8894 l
430.6986 656.8894 l
f*
530.581 668.8894 m
530.581 656.3894 l
530.081 656.3894 l
530.081 668.8894 l
f*
530.081 656.3894 m
431.1986 656.3894 l
431.1986 656.8894 l
530.081 656.8894 l
f*
575.9989 656.3894 m
530.581 656.3894 l
530.581 656.8894 l
575.9989 656.8894 l
f*
320.8507 656.3894 m
320.8507 643.8895 l
320.3507 643.8895 l
320.3507 656.3894 l
f*
320.3507 643.8895 m
199.9998 643.8895 l
199.9998 644.3895 l
320.3507 644.3895 l
f*
431.1986 656.3894 m
431.1986 643.8895 l
430.6986 643.8895 l
430.6986 656.3894 l
f*
430.6986 643.8895 m
320.8507 643.8895 l
320.8507 644.3895 l
430.6986 644.3895 l
f*
530.581 656.3894 m
530.581 643.8895 l
530.081 643.8895 l
530.081 656.3894 l
f*
530.081 643.8895 m
431.1986 643.8895 l
431.1986 644.3895 l
530.081 644.3895 l
f*
575.9989 643.8895 m
530.581 643.8895 l
530.581 644.3895 l
575.9989 644.3895 l
f*
575.9989 622.1392 m
199.9998 622.1392 l
199.9998 622.6393 l
575.9989 622.6393 l
f*
0.83 0.64 0.02 0 k
200.0126 609.052 m
350.7591 609.052 l
h
f*
0 g
7.9999 0 0 7.9999 200.0125 708.7181 cm
BT
/F12 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(2.)Tj
1.1763 0 Td
(Distributio)Tj
4.6489 0 Td
(n)Tj
0.7795 0 Td
(of)Tj
1.0559 0 Td
(SMD)Tj
2.3457 0 Td
(subtypes)Tj
3.8268 0 Td
(within)Tj
2.9127 0 Td
(and)Tj
1.7787 0 Td
(between)Tj
3.6142 0 Td
(groups)Tj
3.0827 0 Td
(\(N)Tj
1.304 0 Td
(=)Tj
0.7866 0 Td
(248\).)Tj
0 Tc
-29.8632 -1.8567 Td
(SMD)Tj
2.3669 0 Td
(Status)Tj
12.9899 0 Td
(Control)Tj
3.5291 0 Td
(Group)Tj
2.9835 0 Td
(\(n)Tj
1.141 0 Td
(=)Tj
0.8008 0 Td
(204\))Tj
-8.4544 -1.1834 Td
(N)Tj
0.9638 0 Td
(\(%\))Tj
12.8268 1.1834 Td
(CRPS)Tj
2.6575 0 Td
(Group)Tj
2.9835 0 Td
(\(n)Tj
1.1481 0 Td
(=)Tj
0.8007 0 Td
(44\))Tj
-7.5898 -1.1834 Td
(N)Tj
0.9709 0 Td
(\(%\))Tj
11.4521 1.1834 Td
(Total)Tj
-41.5704 -2.7496 Td
(Non-SM)Tj
3.5362 0 Td
(D)Tj
/F8 1 Tf
11.941 0 Td
(178)Tj
1.6654 0 Td
(\(87.25\))Tj
12.1324 0 Td
(29)Tj
1.1835 0 Td
(\(65.91\))Tj
11.2394 0 Td
(207)Tj
-41.6979 -1.5591 Td
(sensory)Tj
3.274 0 Td
(over-re)Tj
2.9126 0 Td
(sponsivenes)Tj
4.7977 0 Td
(s)Tj
4.4929 0 Td
(23)Tj
1.1906 0 Td
(\(11.27\))Tj
12.6072 0 Td
(11\(25.00\))Tj
12.4229 0 Td
(34)Tj
-41.6979 -1.5661 Td
(sensory)Tj
3.274 0 Td
(under-re)Tj
3.5575 0 Td
(sponsivenes)Tj
4.7977 0 Td
(s)Tj
3.848 0 Td
(3)Tj
0.7087 0 Td
(\(1.47\))Tj
13.0891 0 Td
(4)Tj
0.7087 0 Td
(\(9.09\))Tj
11.7142 0 Td
(7)Tj
-41.6979 -2.3386 Td
(Non-SMD,)Tj
4.7126 0 Td
(no)Tj
1.2898 0 Td
(sensory)Tj
3.274 0 Td
(modulation)Tj
4.9323 0 Td
(dysfunction)Tj
0.83 0.64 0.02 0 k
/F10 1 Tf
-0.025 Tc
-14.2087 -2.2536 Td
(https://d)Tj
3.0827 0 Td
(oi.org/10.1371/j)Tj
5.9173 0 Td
(ournal.pon)Tj
3.9827 0 Td
(e.0201354.t00)Tj
5.3859 0 Td
(2)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
199.9998 171.3067 m
575.9997 171.3067 l
575.9997 170.8067 l
199.9998 170.8067 l
f*
371.8837 170.8067 m
371.8837 158.3067 l
371.3837 158.3067 l
371.3837 170.8067 l
f*
371.3837 158.3067 m
199.9998 158.3067 l
199.9998 158.8068 l
371.3837 158.8068 l
f*
419.2163 170.8067 m
419.2163 158.3067 l
418.7163 158.3067 l
418.7163 170.8067 l
f*
418.7163 158.3067 m
371.8837 158.3067 l
371.8837 158.8068 l
418.7163 158.8068 l
f*
517.7027 170.8067 m
517.7027 158.3067 l
517.2026 158.3067 l
517.2026 170.8067 l
f*
517.2026 158.3067 m
419.2163 158.3067 l
419.2163 158.8068 l
517.2026 158.8068 l
f*
575.9991 158.3067 m
517.7027 158.3067 l
517.7027 158.8068 l
575.9991 158.8068 l
f*
371.8837 158.3067 m
371.8837 145.8068 l
371.3837 145.8068 l
371.3837 158.3067 l
f*
371.3837 145.8068 m
199.9998 145.8068 l
199.9998 146.3068 l
371.3837 146.3068 l
f*
419.2163 158.3067 m
419.2163 145.8068 l
418.7163 145.8068 l
418.7163 158.3067 l
f*
418.7163 145.8068 m
371.8837 145.8068 l
371.8837 146.3068 l
418.7163 146.3068 l
f*
466.5489 158.3067 m
466.5489 145.8068 l
466.0489 145.8068 l
466.0489 158.3067 l
f*
466.0489 145.8068 m
419.2163 145.8068 l
419.2163 146.3068 l
466.0489 146.3068 l
f*
517.7027 158.3067 m
517.7027 145.8068 l
517.2026 145.8068 l
517.2026 158.3067 l
f*
517.2026 145.8068 m
466.5489 145.8068 l
466.5489 146.3068 l
517.2026 146.3068 l
f*
575.9991 145.8068 m
517.7027 145.8068 l
517.7027 146.3068 l
575.9991 146.3068 l
f*
371.8837 145.8068 m
371.8837 133.3069 l
371.3837 133.3069 l
371.3837 145.8068 l
f*
371.3837 133.3069 m
199.9998 133.3069 l
199.9998 133.8069 l
371.3837 133.8069 l
f*
419.2163 145.8068 m
419.2163 133.3069 l
418.7163 133.3069 l
418.7163 145.8068 l
f*
418.7163 133.3069 m
371.8837 133.3069 l
371.8837 133.8069 l
418.7163 133.8069 l
f*
466.5489 145.8068 m
466.5489 133.3069 l
466.0489 133.3069 l
466.0489 145.8068 l
f*
466.0489 133.3069 m
419.2163 133.3069 l
419.2163 133.8069 l
466.0489 133.8069 l
f*
517.7027 145.8068 m
517.7027 133.3069 l
517.2026 133.3069 l
517.2026 145.8068 l
f*
517.2026 133.3069 m
466.5489 133.3069 l
466.5489 133.8069 l
517.2026 133.8069 l
f*
575.9991 133.3069 m
517.7027 133.3069 l
517.7027 133.8069 l
575.9991 133.8069 l
f*
371.8837 133.3069 m
371.8837 120.8069 l
371.3837 120.8069 l
371.3837 133.3069 l
f*
371.3837 120.8069 m
199.9998 120.8069 l
199.9998 121.307 l
371.3837 121.307 l
f*
419.2163 133.3069 m
419.2163 120.8069 l
418.7163 120.8069 l
418.7163 133.3069 l
f*
418.7163 120.8069 m
371.8837 120.8069 l
371.8837 121.307 l
418.7163 121.307 l
f*
466.5489 133.3069 m
466.5489 120.8069 l
466.0489 120.8069 l
466.0489 133.3069 l
f*
466.0489 120.8069 m
419.2163 120.8069 l
419.2163 121.307 l
466.0489 121.307 l
f*
517.7027 133.3069 m
517.7027 120.8069 l
517.2026 120.8069 l
517.2026 133.3069 l
f*
517.2026 120.8069 m
466.5489 120.8069 l
466.5489 121.307 l
517.2026 121.307 l
f*
575.9991 120.8069 m
517.7027 120.8069 l
517.7027 121.307 l
575.9991 121.307 l
f*
575.9991 99.0567 m
199.9998 99.0567 l
199.9998 99.5567 l
575.9991 99.5567 l
f*
0.83 0.64 0.02 0 k
200.0126 86.0031 m
350.7591 86.0031 l
h
f*
0 g
7.9999 0 0 7.9999 200.0125 176.1448 cm
BT
/F12 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(3.)Tj
1.1763 0 Td
(Odds-ratio)Tj
4.5709 0 Td
(s)Tj
0.6024 0 Td
(95%)Tj
1.9559 0 Td
(Wald)Tj
2.4733 0 Td
(confidence)Tj
4.7126 0 Td
(limits)Tj
2.615 0 Td
(and)Tj
1.7858 0 Td
(level)Tj
2.0977 0 Td
(of)Tj
1.0559 0 Td
(significance)Tj
5.1166 0 Td
(of)Tj
1.063 0 Td
(risk)Tj
1.7858 0 Td
(factors)Tj
3.0615 0 Td
(for)Tj
1.4598 0 Td
(CRPS)Tj
2.6292 0 Td
(\(N)Tj
1.3039 0 Td
(=)Tj
0.7866 0 Td
(248\).)Tj
0 Tc
-42.8034 -1.8567 Td
(Level/Var)Tj
4.0677 0 Td
(iable)Tj
17.6671 0 Td
(OR)Tj
5.9173 0 Td
(95%)Tj
1.9843 0 Td
(Confidence)Tj
5.0174 0 Td
(Limits)Tj
5.3079 0 Td
(p-value)Tj
/F8 1 Tf
-39.9617 -1.559 Td
(sensory)Tj
3.274 0 Td
(over-re)Tj
2.9126 0 Td
(sponsivenes)Tj
4.7977 0 Td
(s)Tj
/F12 1 Tf
0.5953 0 Td
(vs)Tj
1.0842 0 Td
(Non-SM)Tj
3.5363 0 Td
(D)Tj
/F8 1 Tf
7.3772 0 Td
(2.68)Tj
5.9174 0 Td
(1.08)Tj
6.3992 0 Td
(5.94)Tj
6.1513 0 Td
(0.0261)Tj
-42.0452 -1.5662 Td
(sensory)Tj
3.274 0 Td
(under-re)Tj
3.5575 0 Td
(sponsivenes)Tj
4.7977 0 Td
(s)Tj
/F12 1 Tf
0.5953 0 Td
(vs)Tj
1.0771 0 Td
(Non-SMD)Tj
/F8 1 Tf
10.2757 0 Td
(8.21)Tj
5.9174 0 Td
(1.72)Tj
5.9173 0 Td
(43.70)Tj
6.6332 0 Td
(0.0079)Tj
/F12 1 Tf
-42.0452 -1.559 Td
(Age)Tj
1.8567 0 Td
(\(per)Tj
1.9771 0 Td
(5)Tj
0.73 0 Td
(years\))Tj
/F8 1 Tf
19.0135 0 Td
(1.34)Tj
5.9174 0 Td
(1.04)Tj
6.3992 0 Td
(1.74)Tj
6.1513 0 Td
(0.0243)Tj
-42.0452 -2.3457 Td
(Non-SMD,)Tj
4.7126 0 Td
(no)Tj
1.2898 0 Td
(sensory)Tj
3.274 0 Td
(modulation)Tj
4.9323 0 Td
(dysfunction)Tj
0.83 0.64 0.02 0 k
/F10 1 Tf
-0.025 Tc
-14.2087 -2.2465 Td
(https://d)Tj
3.0827 0 Td
(oi.org/10.1371/j)Tj
5.9173 0 Td
(ournal.pon)Tj
3.9827 0 Td
(e.0201354.t00)Tj
5.3859 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 472.2519 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(SMD)Tj
2.4165 0 Td
(is)Tj
0.9213 0 Td
(associated)Tj
4.9181 0 Td
(with)Tj
1.963 0 Td
(CRPS)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02013)Tj
4.089 0 Td
(54)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(9,)Tj
1.0418 0 Td
(2018)Tj
34.5758 0 Td
(6)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
195 0 obj
<>stream
endstream
endobj
196 0 obj
<>stream
endstream
endobj
197 0 obj
<>stream
endstream
endobj
198 0 obj
<>stream
endstream
endobj
199 0 obj
<>stream
endstream
endobj
200 0 obj
<>stream
endstream
endobj
201 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
202 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 206 0 R/Contents 207 0 R/TrimBox[0 0 612 792]>>
endobj
204 0 obj
<>
endobj
208 0 obj
<>
endobj
209 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /TeX_CM_Roman def
/FontType 1 def
/FontBBox {-31 -250 1000 750} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Roman) readonly def
/BaseFontName (TeX_CM_Roman) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
dup 10 /C10 put
dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
dup 19 /C19 put
dup 20 /C20 put
dup 21 /C21 put
dup 22 /C22 put
dup 23 /C23 put
dup 24 /C24 put
dup 25 /C25 put
dup 26 /C26 put
dup 27 /C27 put
dup 28 /C28 put
dup 29 /C29 put
dup 30 /C30 put
dup 31 /C31 put
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤.vA2*Sr 2@Y0}S/8W}efFz~"7Mԗ3T3#mAE=90}c:o|y$)|DKf{(!✱դs'Xt{r6\C~-x{jFҘ{@]##')\}7l"ۂ8c.)a0KcyZ$FX(uØ!{uh\[l^d*BֿAJyPOM lJvNab?$h:`/A[ 88hxtXX*UT<NoR^@z
!cef WE(3ZmC:A~Y&w$ř/LGjq6Sπ4E0rrdyrx˫3JLqT|heT[?bqv\6Kw0ֻ#[[#Fo碜m w#ojsnlϴ=9 Żԕ)~\]G˧Ž9#iiՋToI.9[ڔl6l_vtK"JfKPč+:
Α/ (kw}
>qoF6EQO8Ql68ůĊɻ֕GNKEvw*70Uz7+*t8w͌`уg;5unV#/-VPoWHY+H%5̶bGPgsPU
v
"h$9;Ap52@\_A-0@i:0&"MW\45@27wRItgtEa5 ew#oH}TȒ)HEY$@W`rTmŽ^xlIC' U:* 3?RCG
hk~sA9+cUɅ;eoYyv@54oR
UeYPΚmu[*՛4z3vIk9UBřR29kӧf4ی4o0H?ǚ<._VhZu*`h>S
ao҄Ã(Kh',9s&/b$fGX==s2:=x?B<Ӂ:ͪbJ*EgDEg|s8, 1 4f&raBڶ]٠}$*U"*/y"7.VgS+'Q6h"3$\އ7U9چۯj1}21WH;=|{pb=x@OѢ^[ngoDU'suIҢ!+VCAb2BsSm
x\=Q,pt響m!.;jX2_f;_$䦐>{ןŌR"=@M
k9٦LnQkջy{yg+_CJ;DU.2qKf ]cj[6$i/@f ^$JnY:4*itKD"_U5Zay";4\.a`a=Bhlru M:%_8Rx=mo9ިӍj&q&dWf?K
$r\;7oU'c{apDT=Zţ!.% c/=3tg|}AGd`#oe )hZ#Č4vQnTERz*uhc}(<T~?ԀlifF!W_Qo0>Tc?gߝv|K{&h{Qza
x
2)3jd@"wSt@![*SZ4\z;,ܵ
❦u@HpΒRMroҜq{z
(`wN
PcT(Sݣ\.]ƿ}/xb)7!P3hQRwYBІd|ՔF ֺw"m%r8= (Ah&x|Fz&E{fup&rxyzNt[AqR9M9N#C1cc9w\GCUN!RaoB$e W-U7ޓweaBoֳD(c6֧droG2tʈmV):ƣDa)r8>HrVm" cu40q?$-@;o,ZUHL6$ {%c#lV_.MBa6[+U3D?rfgv,m,۠8?4}ݏşcVRy5NRP_\Wz囔Zf}&5}Hf
ڗrm@0|NL}B婭$=;Ӻ֚Dȷ;NXf9&SR85+&W]
(
ţ8q ZITrM|bd
s娶 u" ]'Q+>@2Yƭ_vh\goܡn<g$wn_` _u\J!!.5^ ϓ/q
-s#+GzKcggh҇*FAV4cOcBGcf)=Bh(CX\@"8O{J
vXgn8nڧML'D/)(tD~/wF+Ќ:/+=z
EE0\a47 =c]c9H5vEYu{[7_G7>;12ч%V3iw\i ejS}K 74E.bo(/@Q-}]8TIռqw=5ѤrXO96z 96$oXIHLg_FeBP$f`>(R6q]htif N}HjV*dMv^?;[:4HFAe@5$۬x"mS~_wOn['[]a5N1&/8yiw; Dm֣@2Ur>xHDAɵFO\[D(ki=|[2Bo)ʽɢ=ȐU;,Э(W]lC!\OV5, aeI+u